Using propensity score matching, Kim et al. find evidence of higher short- and long-term risk of adverse neuropsychiatric outcomes in Korean and Japanese cohorts of individuals infected with SARS-CoV-2 than in the general population.
New stem cell research opens up new opportunities for discovery. Schizophrenia is a complex neuropsychiatric disorder, the intricacies of which are not yet fully grasped. While its symptoms usually manifest during late adolescence or early adulthood, it's believed that its roots can be traced back
"#PostCovid participants with #neuropsychiatric symptoms demonstrated compensatory neural processes with greater usage of alternate #brain regions, and reorganized networks, to maintain normal performance during working memory tasks. BOLD-fMRI was sensitive for detecting #brainAbnormalities that correlated with various quantitative #neuropsychiatric symptoms."
#LongCovid #Covid #Covid19 #science #corona
https://n.neurology.org/content/early/2023/04/26/WNL.0000000000207309
Background and Objectives: Post-COVID condition (PCC) is common and often involves neuropsychiatric symptoms. This study aimed to use blood-oxygenation-level-dependent functional MRI (BOLD-fMRI) to assess whether participants with PCC had abnormal brain activation during working memory (WM), and whether the abnormal brain activation could predict cognitive performance, motor function or psychiatric symptoms. Methods: The PCC participants had documented COVID-19 at least 6 weeks prior to enrollment. Healthy control participants had no prior history of COVID-19 and negative tests for SARS-CoV-2. Participants were assessed using three NIH-Toolbox (NIHTB) batteries for Cognition (NIHTB-CB), Emotion (NIHTB-EB) and Motor function (NIHTB-MB), as well as selected tests from the Patient-Reported Outcomes Measurement Information System (PROMIS). Each had BOLD-fMRI at 3 Tesla, during WM (N-back) tasks with increasing attentional/WM load. Results: 169 participants were screened; 50 fulfilled the study criteria and had complete and usable datasets for this cross-sectional cohort study. 29 PCC participants were diagnosed with COVID-19 242±156 days earlier, had similar ages (42±12 vs. 41±12 years), gender proportion (65% vs. 57%), racial/ethnic distribution, handedness, education, and socioeconomic status, as the 21 uninfected healthy controls. Despite the high prevalence of memory (79%) and concentration (93%) complaints, the PCC group had similar and normal performance on the NIHTB-CB as the controls. However, PCC participants had greater brain activation than the controls across the network (p-FDR-corrected=0.003, T-max=4.17), with greater activation in the right superior frontal gyrus (p=0.009, Cohen’s- d =0.81, 95%CI [0.15-1.46]) but lesser deactivation in the default mode regions (p=0.001, d =1.03, 95%CI [0.61-1.99]). Compared to controls, PCC participants also had poorer dexterity and endurance on the NIHTB-MB, higher T-scores for negative affect and perceived stress, but lower T-scores for psychological well-being on the NIHTB-EB, as well as more pain symptoms and poorer mental and physical health on measures from PROMIS. Greater brain activation also predicted poorer scores on measures that were abnormal on the NIHTB-EB. Discussion: PCC participants with neuropsychiatric symptoms demonstrated compensatory neural processes with greater usage of alternate brain regions, and reorganized networks, to maintain normal performance during WM tasks. BOLD-fMRI was sensitive for detecting brain abnormalities that correlated with various quantitative neuropsychiatric symptoms.
Idk who needs to hear this, but it's totally reasonable to cry all the way home after the first half of a #neuropsychiatric #evaluation
Pretty certain this will be my last #AutismAcceptanceMonth without a formal diagnosis of AuDHD.
#AuDHD #Autism #actuallyautustic #actuallyadhd #Autistic #Diagnosis #AutismDiagnosis
Over the last decade, #scientists have explored the association between #GutMicrobiota & the #brain & affected #neurologic manifestations. These #studies have indicated that #gut #microbiota #influences #neurogenesis , #behavior , #emotions , #CognitiveDevelopment & progression of #neuropsychiatric diseases. A #NewStudy published in the journal #FrontiersInMedicine reviewed recent literature on the link between gut microbiota, the brain & #NeurologicalDisorders.
https://www.news-medical.net/amp/news/20230319/Gut-microbiomes-and-mental-health-how-do-they-interact.aspx
Scientific Frontline
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