Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Oleic acid from olive oil reduces infection-related bone loss with age

New re…
#dining #cooking #diet #food #MediterraneanOliveOil #OliveOil ##inflammation #aging #Antibiotic #Bacterial #Bone #cardiovasculardisease #Diabetes #ImmuneResponse #Mediterranean #MediterraneanDiet #Microbiome #MouseModel #Olive #Osteoclast #osteoporosis #Periodontitis #Research #saturatedfats #stress #teeth
https://www.diningandcooking.com/2154139/oleic-acid-from-olive-oil-reduces-infection-related-bone-loss-with-age/

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

Macrophages are essential immune cells that reside in all tissues. Some macrophages arise from monocytes in the blood, but during fetal development they also come from a unique pathway!

We still have a lot to learn, but here I'll describe how Zhao et al. (2023) used mouse models to uncover hints about which progenitor cells create tissue-macrophages.

https://doi.org/10.1016/j.celrep.2023.113364

#Macrophages #MouseModel #Immunology #Immunity #scRNAseq #FlowCytometry #Research #JournalArticle #JournalClub

1/9🧵

Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.

https://doi.org/10.1016/j.immuni.2023.06.005

By @maxevrard
#Immunology #TissueImmunity

New results in a mouse model "demonstrate the rapid and potent effects of [artificial light at night] on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease."

https://www.cell.com/iscience/fulltext/S2589-0042(23)01073-8

#Neuroscience #Chronobiology #MouseModel #ModelOrganism #Cerebrovascular #ALAN

#scientists previously believed silent synapses were only present during early development; however, #mousemodel research found that about 30% of all synapses in the cortex are silent.

https://scitechdaily.com/surprising-discovery-mit-neuroscientists-find-that-adult-brain-is-filled-with-millions-of-silent-synapses/