Mastodawn

@MaFu55 @dzne They find that increased C4 reduces #synapse density while decreasing #microglial contact with synapses. This challenges the simple "more pruning" view and points to disrupted microglial surveillance and signaling instead. Together, this links C4–CR3 signaling to circuit-level dysfunction, providing a mechanistic bridge between immune genetics and synaptic pathology in #schizophrenia.

Huge congratulations to Nala & Naya and all co-authors on this excellent work! 🎉

Fabrizio Musacchio 1d ago

🧠 New publication from our lab 🥳! Nala ( @MaFu55 Lab, @dzne) & Naya (Corentin Le Magueresse Lab) show that #schizophrenia-associated complement C4 impairs #synaptic connectivity and alters #microglia–synapse interactions via #CR3 signaling.

📝 https://doi.org/10.1016/j.celrep.2026.117161

#Neuroscience 🧪 #2pImaging

ira 1d ago

did some art like a did many years ago #myart #abstract #schizophrenia #schizospec #art

Hassmeister 1d ago

Ein Text an der Wand in einer geschlossenen Psychiatrie in Hamburg schenkt den Insassen Hoffnung. Keine Sorge, ich war nur zu Besuch.

#Health #Hope #Schizophrenia #Psychosis #QuantumWitchery #QWP

Hope 4d ago

Today I dolled myself up to go to my big brother and celebrate my birthday 🩷 I also upcycled a denim jacket I bought around 5-6 year ago, but haven't worn much lately because of the "us. army" patch and a eagle patch. But I took some red thread and ran over it with my sewing machine, so now I can proudly wear it again 💅 Because fuck usa and fuck Trump 🖕🩷

#mentalhealth #schizophrenia #adhd #cptsd #trauma #depression #ootd #anxiety #recovery #psychology #mentor #recoverymentor #redhair #fashion #fashionphotography #upcycling #upcycle #fuckusa #fucktrump

Hope 6d ago

Today I spend the day with my social worker and planning some stuff with her 🩷 Later they called from det DAT therapy center and offered me a spot! I'm so excited for it 🫶 I also had some energy to be creative with some photos, they turned out this way 📸 #mentalhealth #schizophrenia #adhd #cptsd #trauma #depression #ootd #anxiety #recovery #psychology #mentor #recoverymentor #redhair #fashion #fashionphotography #dat #dattherapy #photoshoot #creativephotos #photo #model #modeling

Traum und Verantwortung e.V.Mar 22

"In “Reframing schizophrenia as a neurodevelopmental syndrome: The scientific and social imperative,” the authors outline a three-part strategy to translate this understanding into practice:
• Reclassify schizophrenia within diagnostic systems as neurodevelopmental
• Rename the condition to better reflect current science and reduce stigma
• Reshape how it is identified and treated, with greater emphasis on earlier recognition and more continuous, developmentally informed care."

"a neurodevelopmental lens also strengthens the rationale for social investment in schizophrenia by positioning biological vulnerability within social contexts that influence developmental trajectories. Early adversity, trauma, and social exclusion can harm neural development, while supportive environments such as stable housing, education, and community integration exert measurable neuroprotective effects".

#Schizophrenia Research,
Volume 292, 2026, Pages 96-102, ISSN 0920-9964, https://doi.org/10.1016/j.schres.2026.03.001