🧠 A molecular atlas of the hippocampus: Mapping RNAs and proteins at synaptic resolution

https://medicalxpress.com/news/2025-09-molecular-atlas-hippocampus-rnas-proteins.html

#brain #neuroscience #hippocampus #omics #instruments #molbio

A molecular atlas of the hippocampus: Mapping RNAs and proteins at synaptic resolution

Researchers at the Max Planck Institute for Brain Research have mapped the molecular landscape of the mouse hippocampus, a region central to learning and memory. By combining RNA and protein profiling with advanced methods to isolate brain regions and synapses, the team identified thousands of molecules with distinct spatial patterns.

Medical Xpress

***🧠 Scientists reversed memory loss with lab-grown “young” immune cells.***

In a groundbreaking preclinical study, scientists at Cedars-Sinai have reversed signs of aging and Alzheimer’s disease in mice using "young" immune cells grown from adult stem cells.

These lab-generated cells, known as mononuclear phagocytes, were infused into aged and Alzheimer’s-model mice, leading to significant improvements in memory and brain health.
The treated mice retained more mossy cells—critical for learning and memory—in the hippocampus, and their microglia, the brain’s primary immune cells, remained healthier and more functional compared to untreated mice.

Although the infused cells did not directly enter the brain, researchers believe they may have triggered protective effects indirectly—either by releasing anti-aging proteins, shedding brain-accessible vesicles, or absorbing harmful, aging-related molecules from the bloodstream. The team now aims to uncover the exact mechanism behind these effects to develop a scalable, personalized therapy. With unlimited potential from stem cell-derived immune cells, this approach could lead to a new class of treatments for age-related cognitive decline and neurodegenerative diseases like Alzheimer’s.

Core breakthrough & research
#MedicalBreakthrough #Neuroscience #RegenerativeMedicine #FutureOfMedicine #LifeSciences #Biotech

Memory & brain health
#MemoryLoss #BrainHealth #CognitiveDecline #Neurodegeneration #AlzheimersResearch #AgingResearch

Therapy specifics
#StemCells #YoungImmuneCells #CellTherapy #Immunotherapy #AntiAgingScience #Hippocampus

Hope & impact
#HopeForPatients #InnovativeMedicine #AgeReversal #NeuroHealing #CuttingEdgeScience

During task performance, the brain must integrate information re goal-related objects with contextual details. This study shows that participants' performance on a #SpatialNavigation task is related to syncing of activity between #hippocampus & #EntorhinalCortex @PLOSBiology https://plos.io/3Vrw8id

Some kinda water horse. Half hippocampus, half kirin. Bought a bunch of watercolors I bought from Temu. I don't use that site anymore, but I'll be honest, the watercolors aren't half bad. 

Apologies for the digital watermark. You can thank AI datascraping for that. #art #hippocampus #kirin

Today, we had a great #iBehave lecture by Yaniv Ziv at the #DZNE. He presented his work on #RepresentationalDrift in the #hippocampus and entorhinal #cortex, studying #PopulationDynamics of freely moving mice 💪 Great insights into how neuronal codes evolve across time!

#neuroscience 🧪 #CompNeuro