The cell that saves your life every day

The cell that saves your life every day

🔬 The Quiet Revolution: When Medicine Learns to Remember
What if borrowed immune cells could save immunocompromised lives?
TVGN489 trial results are paradigm-shifting.
Cancer patients cleared COVID in 4 days. The donor cells stayed active for 6 MONTHS—defying everything we thought we knew about rejection.
This isn't just about COVID. It's about shared immunity as community care.
🎧 Listen: https://www.buzzsprout.com/2405788/episodes/405788
📖 Essay: https://helioxpodcast.substack.com/publish/post/74853743
14 min • S5 E39 • Heliox: Where Evidence Meets Empathy
#COVID19 #CellularTherapy #Immunology #MedicalResearch #LongCOVID #Immunocompromised #TCells #HealthScience #Podcast #Medicine
📢 Call for speakers
We are looking for early-career researchers to speak in FocalPlane's mini-symposium run together with the popular membrane trafficking webinar series organised by Francesca Bottanelli, Fèlix Campelo and Ishier Raote.
Application deadline: Sunday 24 August
Find out more:
#FocalPlaneFeatures #Microscopy #MembraneTrafficking #Cells #TCells #ECR #ImmunologicalSynapse #MembraneDynamics #Microscope #CellBiology
'Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia' - a Genes & Diseases article on #ScienceOpen:
🔎 https://www.scienceopen.com/document?vid=a1a783a1-5180-487b-b736-d5d814a5fb75
#CancerImmunology #LeukemiaResearch #TCells #SingleCellSequencing
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9200406e246">The immune microenvironment plays an important role in leukemia treatment. However, a specific single-cell profiling of the immune alteration in bone marrow of chronic myeloid leukemia (CML) patients is still lacking. We performed multi-level single-cell sequencing to systematically decipher the bone marrow T cell atlas of CML patients. The results exhibited extensive changes of T cells, including the decreased CD4 T cells and increased CD8 T cells in the CML bone marrow. Subpopulation analysis revealed a significant increase of CD8 terminal effector (TE) cells and a significant decrease of CD4 naïve T cells. T cell receptor sequencing showed that the overall diversity of the T cell receptor repertoire was reduced in CML, with the exception of the CD8 TE cell. In addition, CD8 TE cells were the main source of gene expression differences in CD8 T cells. Intercellular communication analysis revealed the altered interaction between CD8 TE and other non-T cells in CML, including neutrophil subtype, indicating the potential regulation of bone marrow microenvironment cells on CD8 TE dynamics. Collectively, our work characterises the alteration of T cell subsets in CML patients at multiple single-cell levels, providing a valuable resource for understanding the immune microenvironment and developing new immune strategies for CML therapy. </p>
I saw a scientifically and potentially clinically rather interesting presentation from Sniper therapeutics, this morning. But do we really need to militarize our technique and therapy names?
What was wrong with the original name Super Engagers?
Additionally, the mechanism of action here seems to be more 'close combat' than 'sniper'.