Rhyothemis"mice have approximately four-times more platelets per microliter than humans"
https://doi.org/10.1016/j.isci.2019.08.035
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y
#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman
Study offers a potential pathway for safer, non-addictive pain management
Researchers from the National University of Singapore (NUS), in collaboration with Peking University, China, have made a discovery regarding the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception.
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
What do you think about a hashtag for posts about mouse / human differences, e.g.,
#MouseVsHuman ?