Mastodawn

Pathophysiology and Jones criteria for Acute Rheumatic Fever USMLE

#USMLEStep1 #MedEd #Cardiology #Pathology #RheumaticFever #GroupAStrep #Pediatrics #Step1Prep #HighYield #MedSchool #InternalMedicine #Immunology #MolecularMimicry #FutureDoctor #StudyGram #MedTwitter #Anki #BoardExams #MedicalStude

https://mymedschool.org/portfolio/u01-17-084-acute-rheumatic-fever-arf/?utm_source=mastodon&utm_medium=jetpack_social

U01.17.084 Acute Rheumatic Fever (ARF): Jones Criteria and Molecular Mimicry

Master the pathophysiology of Acute Rheumatic Fever (U01.17.084) for USMLE Step 1. Learn about Group A Streptococcus, Type II hypersensitivity, Aschoff bodies, and the Jones criteria. High-yield guide on mymedschool.org.

mymedschool.org

David Ojcius 1d ago

An anaerobic pathogen rewires host #metabolism to fuel oxidative growth in the inflamed gut.

ETBF uses its toxin to reshape epithelial metabolism, creating a local oxidative niche that fuels its gut colonization.

#OpenAccess #inflammation #microbiology #immunology

https://www.ojcius.net/post/an-anaerobic-pathogen-rewires-host-metabolism-to-fuel-oxidative-growth-in-the-inflamed-gut

David Usharauli 2d ago

1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.

⬇️

#science
#immunology
#Foxp3
#Tregs

https://www.science.org/doi/10.1126/sciimmunol.aed2111

Scientific Frontline 3d ago

The absence of a specific fatty acid molecule known as 12-HETE in the blood of pregnant women significantly increases the risk of their children developing childhood #asthma and early respiratory infections.
#Pediatrics #Immunology #Pulmonology #PublicHealth #sflorg
https://www.sflorg.com/2026/05/med05012601.html

Mothers without specific fatty acid in the blood more often have children with asthma

Learn how lacking the maternal 12-HETE fatty acid elevates childhood asthma risk and alters the protective benefits of prenatal omega-3 supplements.

David Usharauli 3d ago

"Celiac disease (CeD) is an autoimmune disorder triggered by dietary gluten."

How can it be considered autoimmune if the initiating antigen, gluten, is a foreign wheat protein?

#science
#immunology
#gluten
#celiac

https://www.nature.com/articles/s41590-026-02506-6

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten - Nature Immunology

Ghosh and colleagues examine the mechanism underlying the long-noncoding RNA lnc13-mediated regulation to gluten tolerance. The authors show lnc13 restrains CD8αβ+ inter-epithelial lymphocyte responsiveness to IL-15 signaling.

Nature

David Usharauli 3d ago

CCR7 ligands promote T cell release from dendritic cells, supporting effector differentiation instead of overstimulation and dysfunction.

#science
#immunology

https://www.science.org/doi/10.1126/science.adq2080

David Ojcius 3d ago

Cytoplasmic DNA sensors and their regulators.

DNA outside nuclei or mitochondria acts as a DAMP, shaping how cells sense cytosolic DNA and drive tissue‑specific inflammatory responses.

#OpenAccess #immunology #inflammation

https://davidojcius.blogspot.com/2026/04/cytoplasmic-dna-sensors-and-their.html

David Usharauli 3d ago

At this point, I believe it is a disservice to the public when journalists present basic immunological research without clear clinical relevance as novel or groundbreaking.

#science
#immunology

https://www.wired.com/story/daniel-davis-immunology-wired-health

Scientists Are Starting to Unlock the Nanoscale Secrets of the Immune System

At WIRED Health, immunologist Daniel Davis detailed the ways in which new technologies are enabling a better understanding of the human immune system.

WIRED

Scientific Frontline 4d ago

Researchers have developed a novel vaccine strategy that successfully generates antibodies capable of neutralizing highly divergent HIV variants by presenting specially designed HIV proteins on liposomes to the immune system.
#Immunology #Virology #Vaccinology #sflorg
https://www.sflorg.com/2026/04/imgy04292602.html

Vaccine strategy induces broadly neutralizing HIV antibodies

Eliciting broadly neutralizing antibodies has been one of the most significant biological hurdles in HIV research

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datum (n=1)4d ago

@mediaevalfishsandwich Still hunting for that stronger "like" than "like" for "thank you that was very informative": that's a great paper!!

RBD-ACE2 binding affinity ... BA.3.2 exhibits disastrously low fitness compared to LP.8.1.1

and in human plasma

in human plasma, BA.3.2 also demonstrated profound humoral immune evasion, with an 11-fold reduction in geometric mean neutralizing titer (NT50) compared to BA.3

and re: what the smarties in the xcancel thread were saying about China's different immune landscape:

Class 1/4 antibodies are prevalent in Chinese populations immunized with inactivated vaccines, where immune imprinting is less pronounced In contrast, mRNA vaccine recipients with stronger immune imprinting rarely develop these antibodies, which may cause divergent neutralization responses against BA.3.2 between these groups.

Figure 3 of that paper, too - very informative!

#COVID #COVID19 #SARSCoV2 #BA32 #immunology