more on immunological effects of sucralose:
Artificial sweetener sucralose: a possible modulator of autoimmune diseases [2023]
https://doi.org/10.1038/s41392-023-01607-0
This is the highlight of our early summer: On Friday 29 June 2026 we meet in a minisymposium world‑leading #microglia researchers like Laura Airas, Caroline Bergner, Christine Stadelmann, Susanne Wolf, Marco Prinz, and Steffen Jung. So exciting! #Immunology @utu.fi @aboakademi.bsky.social
I'm wondering if/how this would affect eosinophilic esophagitis, since sucralose/Splenda is used to make a slurry with topical steroid for treatment. Patients are told to use as much as 20 packets of Splenda, though most only use 2 and some use honey or applesauce instead:
https://www.reddit.com/r/EosinophilicE/comments/1c0pcwa/20_packets_of_splenda/
Artificial sweetener may interfere with immunotherapy | Damon Runyon Cancer Research Foundation
17 Dec 2025
https://www.damonrunyon.org/discovery/artificial-sweetener-may-interfere-immunotherapy
New research from Damon Runyon-Dale F. Frey Breakthrough Scientist Abigail E. Overacre-Delgoffe, PhD, and her lab at the University of Pittsburgh suggests that sucralose—the sugar substitute found in many “sugar-free” sodas, yogurts, and snack foods—may interfere with cancer immunotherapy. Their findings indicate that the widely used artificial sweetener changes the composition of the gut microbiome in ways that weaken patients’ immune systems and blunt the effectiveness of immune checkpoint inhibitors, a class of drugs that unleash T cells to attack tumors.
Scientific Frontline
Rhyothemis
Yliopistobotti
Science HR