drcaplanApr 8
Blissful ignorance is a vibe.
But so is coughing up phlegm for 20 minutes after a “clean” hit.
If you’d rather not know what’s cooking in your cart, skip this post.
If you’re curious? You might not unsee it.
🔗 https://doctorapprovedcannabis.substack.com/p/why-cannabis-makes-you-cough-and?r=58khz
#VaporScience #TRPChannels #CannabisMedicine #DoctorKnowsBest
🔬 Why Cannabis Makes You Cough — And What You Can Do About It

What it says about your method, your materials—and your body.

Doctor Approved
RhyothemisDec 30

Study offers a potential pathway for safer, non-addictive pain management

https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx

"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."

They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -

Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y

#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman

Study offers a potential pathway for safer, non-addictive pain management

Researchers from the National University of Singapore (NUS), in collaboration with Peking University, China, have made a discovery regarding the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception.

News-Medical
RhyothemisDec 9

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

RhyothemisDec 7

research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014

#ALDH2 #TRPV1 #TRPchannels #mitochondria #ToRead

Dhananjay ThakurAug 28, 2024

Getting on to the faculty job market this season - scary and exciting!

My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior

with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).

Here to share stories on this academic life, research, technical tips and tricks.

Very excited to learn new things from you all!

RhyothemisJun 28, 2024

Today's reading topic to distract/entertain/self-soothe -

Would messing with ankyrin mess up both Piezo and TRP channel function? What would be the implications for immune function?

articles to read:

Human ankyrins and their contribution to disease biology: An update
https://www.ias.ac.in/article/fulltext/jbsc/045/0146

Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus
https://doi.org/10.1152/ajpcell.00368.2020

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822220/

Roles of TRP and PIEZO receptors in autoimmune diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140548/

okay, that should be enough

also an hour of body scan meditation
& some Perilla tea

#TRPchannels #Piezo #ENaC #ankyrin #autoimmunity #ImmuneSystem

RhyothemisFeb 2, 2024

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/

#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain and migraine. This review focuses on the current state of this progress.

PubMed Central (PMC)
Show threadRhyothemisJan 13, 2024

I should probably mention that like the woman in 1st case report, I also have MCAS symptoms, as well as other pain and paresthesia in my hands and elsewhere. I had a colonoscopy a few months after this started and for the prep I ate mostly just white rice and tapioca - no fruit or veg. I felt much, much better on the colonoscopy prep diet. Since then my diet has become quite restricted as I noticed more pain when I ate cruciferous veg, alliums, legumes - lots of stuff.

So it is possible some of my erythromelalgia symptom improvement is due to having a limited diet - which is probably not so great for long term health overall.

I have wondered if there is TRP channel involvement since isothiocyanates and other food components can activate TRP channels, as can heat exposure.

Then there is the possibility of a connection to mast cells to consider.

#TRPchannels #MCAS #erythromelalgia

RhyothemisJun 7, 2023

https://youtu.be/iRlrA-B7lOU

"A mechanical stimulus to skeletal muscle activates the sympathetic nervous system during exercise. ... Our data suggests that TRPV4 plays an important role in mechanotransduction contributing to the cardiovascular responses during exercise. "

#physiology #TRPV4 #TRPchannels

PHYSIOLOGY SHORTS: Antagonism of TRPV4 channels reduces mechanotransduction in rat skeletal muscle

YouTube
RhyothemisJun 2, 2023

news article:
https://www.sciencealert.com/ultrasound-induces-torpor-like-state-in-animals-experiment-shows

"the ultrasound was activating the TRPM2 ion channel in neurons of the hypothalamus preoptic area, demonstrating this is an ultrasound-sensitive ion channel that plays a role in sending animals into
[ultrasound-induced hypothermia & hypometabolism]"

#metabolism #torpor #TRPchannels #SpaceMedicine #Brain

Ultrasound Induces Torpor-Like State in Animals, Experiment Shows

Torpor is a helpful trick for surviving lean times, helping some mammals and birds reduce their body temperature and metabolic rate to safely snooze through hardship.

ScienceAlert