Coffee (Team CW)"I can't see anything!"
- "Sir. You're trying to use the nociceptors for vision. They literally can't."
CITO GreenhouseUnlocking the Secrets of the Mind and Body: A Journey into Interoception and Emotion
#MindBodyConnection #Interoception #BloodBrainBarrier #Emotions #Nociception #Antinociception #SelfAwareness #MentalHealth #Neuroscience #ExploreYourMind #BrainScience #Mindfulness #EmotionalIntelligence #ScienceExplained #GeomagneticField
RhyothemisStudy offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y
#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman
Study offers a potential pathway for safer, non-addictive pain management
Researchers from the National University of Singapore (NUS), in collaboration with Peking University, China, have made a discovery regarding the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception.
Albert CardonaPhD Position in Neural Mechanisms of Nociceptive Perception and Modulation, in the lab of Carlotta Martelli, Johannes Gutenberg University Mainz, Germany.
To apply, write to Martelli directly, see below:
Understanding the roots of chronic pain
"A team of researchers led by Oscar Sánchez-Carranza in Professor Gary Lewin's lab at the Max Delbrück Center have identified a new function for the PIEZO2 protein -- in mediating chronic pain hypersensitivity. The research suggests a new target for analgesics and potentially explains why pain medications that target voltage gated sodium channels have been disappointing as clinical targets. "
https://www.sciencedaily.com/releases/2024/07/240711111439.htm
#ChronicPain #Piezo #Piezo2 #nociception #neuroscience #fibromyalgia
Dr. Jarred Younger, PhD will be doing a weekly YouTube series on the latest research on pain and chronic illnesses such as fibromyalgia, ME/CFS, Long Covid and Gulf War Syndrome.
🙂 ❤️
https://youtu.be/ZWWM6duVScE?si=VSatnYUYwMlxlUQX
#fibromyalgia #ChronicPain #MECFS #LongCovid #GulfWarSyndrome
#GulfWarIllness #MCAS
#AutoimmuneDiseases
#neuroinflammation #nociception #Pain #inflammation
1 - Introduction
I finally took a picture of my hand after washing in warm water. The turning-red thing has been going on for a couple of years and it was much worse when it first started - but I could never remember to take a picture back then. I get a bit more brain-foggy than usual when it happens. I think it's erythromelalgia. It used to burn and hurt, but not much, if at all, these days. My feet used to do it, too - either triggered by taking a hot shower or when working in the heat outdoors. That doesn't happen anymore. Maybe the low dose naltrexone helped, or maybe it was just time.
I got the LDN Rx online after reading this case report. The patient had worse symptoms than me (1). I asked for the LDN based on other chronic pain and eczema, since I had diagnoses for those and they are recognized indications for LDN.
I noticed her 2nd and 3rd toes are a bit fused, like mine. Not quite syndactyly. There's another case report on a baby boy with an SCN9A/Nav1.7 mutation who had 2nd and 3rd toe syndactyly along with pain insensitivity. His mother also had the mutation and
2nd and 3rd toe syndactyly, but she had pain hypersensitivity. I have wondered about the difference in phenotype being due to sex differences.
Under 'Treatment' in the 2nd case report, naloxone is discussed as a possibility, but no information is given as to whether the patient was given naloxone or his response.
1 - https://doi.org/10.25251/skin.4.3.15
2 - CW: there are disturbing pictures in this article of injuries to the baby boy's hands caused by him chewing on them.
https://pubmed.ncbi.nlm.nih.gov/30834170/
#erythromelalgia #pain #LowDoseNaltrexone #SCN9A #nociception #SodiumChannels
SKIN The Journal of Cutaneous Medicine
Erythromelalgia is a rare condition that may be associated with a variety of underlying conditions and can be refractory to therapy. We report a case of a patient with mast cell activation syndrome (MCAS) who developed erythromelalgia and responded to low dose naltrexone (LDN).
on my to-read list:
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
https://doi.org/10.1038/s41467-023-37963-2
#Pain #gympietides #nociception #SodiumChannels #TMEMchannels #NaturalProducts
Animalogic put out an interesting Floralogic episode on the extreme, long-lasting pain caused by gympie gympie - a plant in the same family as stinging nettle -
Gympie Gympie Is Doing Everything It Can To Ruin Your Life
https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen
It's an Australian plant, of course.
"Altering the activation threshold, combined with effects upon inactivation, likely leads to nociceptor activation and the sensation of pain, akin to biophysical changes observed in painful conditions associated with NaV1.7 [SCN9A] gain-of-function mutations such as inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD), respectively ... As the gympietides bear little similarity to any other known NaV modulators and display unusual effects particularly on NaV inactivation, it is difficult to predict possible binding sites at this point. However, based on activity of animal venom–derived toxins and the biophysics of NaV gating, the extracellular loops of the domain IV voltage sensor could be a possible binding site."
https://doi.org/10.1126/sciadv.abb8828
#Pain #nociception #NaturalProducts #erythromelalgia #gympietides #SodiumChannels #SCN9A
Gympie Gympie Is Doing Everything It Can To Ruin Your Life
M'dame Jo"We're a society pushed past the point of exhaustion, forced to perpetuate systems with no reward and no motivation, egged on by tedious exercises in mindfulness and wishful thinking, by a small group of pampered babies who never learned life's most valuable lesson: when to quit."
