Study offers a potential pathway for safer, non-addictive pain management

https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx

"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."

They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -

Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y

#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman

research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014

#ALDH2 #TRPV1 #TRPchannels #mitochondria #ToRead

Capsaicin, the active compound in chili peppers, binds to TRPV1 receptors in your mouth, which are usually responsible for detecting heat or physical abrasion. What you detect as spicy, your brain is technically understanding to be pain.

#science #sciencefacts #Capsaicin #trpv1 #spicy #burn #pain #chilipeppers

I've been making kefir for a few weeks. It did not really 'work' until I switched from using UHT goat milk to regular pasteurized cow milk. UHT alters milk proteins and this can cause problems with fermentation. I'm currently getting good results mixing UHT goat and lowfat cow milk at around 1:3 .

I also recently tried doing a 2nd ferment with lemon peel. I juice the lemons and save the peel by freezing. After sifting out the kefir grains I add in the frozen peel of half a lemon and let it ferment for another 12 hours.

With that amount of peel, there is a bit of a bitter undertone - but I like the lemon flavor and overall quality of the kefir.

My sinuses seem to open up immediately when I drink it.

I also noticed something interesting when I drank some while eating a radish. This batch of radishes was extremely spicy, but there seemed to be no heat at all when I ate the radish and lemon kefir together.

Lemon contains eriodictyol, a bitter flavonoid, that antagonizes TRPV1 -
https://doi.org/10.1016/j.bcp.2010.11.004

#NaturalProducts #FunctionalFoods
#eriodictyol #kefir #TRPV1

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain

"Transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as a pain killer, since systemic antagonism induces hyperthermia. Two articles in this issue of the JCI report phenotypes from separate, rare missense mutations of human TRPV1."

#neuroscience #SensoryNeuroscience #trpv1

https://www.jci.org/articles/view/167338