L'allenamento del padre migliora la salute dei figli. L'eredità nel movimento, scoperto il meccanismo molecolare che permette di trasmettere i benefici dell'attività fisica alla prole. La chiave è nei microRna presenti negli spermatozoi, che agiscono come interruttori genetici migliorando resistenza e metabolismo. Che lo stile di vita dei genitori influenzi la...
#allenamento #epigenetica #geniereditari #metabolismo #microrna #mitocondri #NCoR1 #spermatozoi
https://scienzamagia.eu/sociale-collettivita/lallenamento-del-padre-migliora-la-salute-dei-figli/
Delphinidin upregulates microRNA-let-7b expression through family with sequence similarity 222 member B
Khoo, H. E., Azlan, A., Tang, S. T. & Lim, S. M. Anthocyanidins and anthocyanins: colored pigments as…
#NewsBeep #News #Headlines #Anthocyanidin #Cellbiology #Chemicalbiology #Fam222B #Geneticscreening #HumanitiesandSocialSciences #Latvia #LV #MicroRNA #multidisciplinary #Science
https://www.newsbeep.com/53145/
Creation and Application of Liposomal Form of MicroRNA for the Treatment of Neurodenegratative Diseases - Cytology and Genetics
Abstract Targeted delivery of active pharmaceutical ingredients, such as microRNAs, is a pressing issue. The use of liposomes as targeted carriers of various therapeutic agents has certain advantages and is currently growing significantly. Liposomes are capable of transporting both hydrophilic and hydrophobic molecules simultaneously. Liposomes have relatively high stability under physiological conditions and controlled release of encapsulated ingredients, and are biocompatible with cell membranes. Liposome-encapsulated microRNA-based drugs may become a certain alternative to classical therapeutic agents in the treatment of neurodegenerative diseases. Neuroinflammation is known to be mediated through complex interactions between cells of the central nervous system (CNS) and the periphery. Although the inflammatory response in the healthy brain is tightly controlled by numerous regulatory mechanisms, deregulation can occur in these processes under pathological conditions. Such deregulation leads to uncontrolled neuroinflammation. Among the main regulators of these processes, microRNAs play an important role. Due to miRNAs, processes can become deregulated, contributing to disease progression, or may reflect a homeostatic attempt by the CNS to prevent excessive damage and restore normal functioning conditions. The paper summarizes the literature data on the creation, properties, and application of the liposomal form of miRNA, in particular msiRNA-101, in the development of Alzheimer’s disease.
https://www.alojapan.com/1304419/japanese-startups-urine-based-cancer-test-shows-early-detection-potential-health/ Japanese startup’s urine-based cancer test shows early detection potential | Health
#CraifInc #EarlyCancerDetection #HealthcareTech #Hokkaido #Japan #JapanNews #Japanese #JapaneseNews #MedicalInnovation #microrna #misignal #news A URINE-based cancer screening kit developed by Japanese startup Craif Inc. has demonstrated encouraging results in detecting early-stage cancer non-invasively, according to a report by Kyodo News. Craif Inc., a spin- …
🚨 Our Frontiers in Molecular Neuroscience review explores how microRNAs (miRNAs) could transform early diagnosis of neurodegenerative diseases 🧠
🧬 Also covers aging & protein PTMs!
📖 https://doi.org/10.3389/fnmol.2024.1386735
#Neuroscience #microRNA #Neurodegeneration #Biomarkers #Alzheimers #OpenScience
Frontiers | MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
Neurodegenerative diseases (ND) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leadin...
SciTech Chronicles. . . . . . . . .Feb 28th, 2025
Some make amends... Some make a wound. Vol II No 53 315 links Curated flavonoidcompounds have an insecticidal effect on corn earworm larvae....
A Comprehensive Review on Liver Regeneration Termination: A Non-Neglectable Phase - Cytology and Genetics
Abstract As the most important organ of detoxification in the body, the liver also has the strong regenerative ability itself. The liver can regenerate after partial hepatectomy (PH) and completely restore to its original mass. Liver regeneration (LR) has become one of research hotspots in the field of regenerative biology. Previous basic studies have predominantly concentrated on the initial and proliferative phases of regenerative response, while a relatively little attention has been paid to the mechanism of proper termination of liver regeneration. In recent years, along with the increasing recognition of the significance of LR termination, the growing researches have been carried out and some achievement has been made in a certain extent. The successful completion of LR is considered to involve many cells, growth factors, signaling pathways, metabolites and other extrahepatic factors. This article will review the progression of research on the mechanism of LR termination after PH in recent years.
Role of MicroRNA Modulated Wnt Pathway in Breast Cancer and Its Therapeutic Use - Cytology and Genetics
Abstract The Wnt pathway plays a key role in cell growth, survival, and self-renewal which is frequently hyperactive in various cancers. It is categorized into canonical and non-canonical Wnt pathways depending upon the influence of the β-catenin protein. Gene expressions are often altered by small non-coding RNAs, known as microRNAs (miRNAs) leading to regulation involving cell-proliferating pathways like Wnt in various cancers, including breast. miRNAs frequently act as an oncogene or a tumor-suppressor depending upon their regulatory roles. In this review article, the significance of the Wnt pathway in cancer progression, most importantly breast cancer is widely explained. The role of miRNAs in modulating varied pathways especially the Wnt pathway in breast cancer is also reviewed here. Breast cancer suppression using new-age miRNA therapeutics is showing promising results and the use of different nanocarriers for therapeutic delivery is increasing its efficacy. Targeting the Wnt pathway and its related genes can show a new path for the treatment of cancer stem cells (CSCs) of breast and other cancers as the Wnt pathway plays a pivotal role in maintaining the stemness of CSCs. Moreover, controlling the Wnt pathway through miRNA nanocarrier can give another dimension to breast cancer therapy by inhibiting aggressive and tricky breast cancer stem cells.
Scienza et Magia
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Cytology and Genetics
Japan
Alo Japan
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John Vaccaro (johniac)