Scientific FrontlineMar 14
Rett syndrome is a severe developmental disorder triggered by mutations in the MECP2 gene, which researchers have recently discovered compromises the structural integrity of developing brain blood vessels. This #genetic mutation causes the overexpression of a specific #microRNA that breaks down the tight seals of the blood-brain barrier, resulting in vascular leakiness that disrupts neural function.
#Neuroscience #CellBiology #Genetics #sflorg
https://www.sflorg.com/2026/03/ns03142601.html
Scientists discover genetics behind leaky brain blood vessels in Rett syndrome

By showing the problem derives from genetic mutations that lead to overexpression of a microRNA, MIT researchers’ study points to potential treatment.

GastroAGIFeb 10

miR147 protects gut mucosa by strengthening epithelial integrity and controlling inflammation.

Knockout → severe colitis, barrier loss, ↑ permeability.

miR147 targets Ndufa4 to maintain metabolic balance + type I IFN signaling.

Therapeutic potential in IBD & colorectal cancer.

#GastroAGI #IBD #MicroRNA #GutHealth

Cytology and GeneticsNov 13
The Potential Impact of microRNA-Related Functional Polymorphisms in the Pathogenesis of Coronary Heart Disease - #microRNA #singlenucleotidepolymorphism #coronaryheartdisease #TaqManAssay #miRNA #SNP #CHD #rs2292832 #rs3746444 #rs11614913 #rs1044165 #rs767649 #MIR196A2 #MIR155 #MIR223 #MIR149 #genetics #medicine - https://link.springer.com/article/10.3103/S0095452725050093
The Potential Impact of microRNA-Related Functional Polymorphisms in the Pathogenesis of Coronary Heart Disease - Cytology and Genetics

Abstract MicroRNAs (miRNAs) are widely referred to as gene regulators for different diseases. Single nucleotide polymorphism (SNP) in miRNA genes affects miRNA transcription, maturation, target specificity, and interaction, contributing to coronary heart disease (CHD). This case-control study aimed to investigate the association of five miRNA SNPs—rs2292832, rs3746444, rs11614913, rs1044165, and rs767649—with CHD risk in the Pakistani population using the TaqMan assay. Among these, rs3746444 showed a significant association with CHD under co-dominant, dominant, heterozygous, and additive inheritance models. Similarly, rs11614913 was linked to CHD under co-dominant, dominant, recessive, and additive models. The SNP rs767649 was associated with CHD across co-dominant, dominant, recessive, heterozygous, and additive models. A strong association between rs1044165 and CHD was observed under the heterozygous model. Variants in MIR499A, MIR196A2, MIR155, and MIR223 emerged as significant genetic risk factors for CHD, whereas MIR149 did not show a meaningful association in this cohort. These findings suggest a potential role of miRNA polymorphisms in CHD pathogenesis; however, further studies with larger sample sizes are required to validate these associations.

SpringerLink
Paul HouleOct 27

💦 Sperm microRNAs may enable transmission of exercise benefits from fathers to children

https://medicalxpress.com/news/2025-10-sperm-micrornas-enable-transmission-benefits.html

#sperm #microrna #rna #inheritance #biology #men #fathers #exercise #epigenetics #health

Sperm microRNAs may enable transmission of exercise benefits from fathers to children

In a recent study published in Cell Metabolism, a research paper provides the first evidence that sperm microRNAs act as carriers of epigenetic information, enabling the intergenerational transmission of paternal exercise capacity and metabolic health, thereby exerting profound effects on offspring development.

Medical Xpress
Scienza et MagiaOct 15

L'allenamento del padre migliora la salute dei figli. L'eredità nel movimento, scoperto il meccanismo molecolare che permette di trasmettere i benefici dell'attività fisica alla prole. La chiave è nei microRna presenti negli spermatozoi, che agiscono come interruttori genetici migliorando resistenza e metabolismo. Che lo stile di vita dei genitori influenzi la...

#allenamento #epigenetica #geniereditari #metabolismo #microrna #mitocondri #NCoR1 #spermatozoi

https://scienzamagia.eu/sociale-collettivita/lallenamento-del-padre-migliora-la-salute-dei-figli/

News BeepAug 11, 2025

Delphinidin upregulates microRNA-let-7b expression through family with sequence similarity 222 member B

Khoo, H. E., Azlan, A., Tang, S. T. & Lim, S. M. Anthocyanidins and anthocyanins: colored pigments as…
#NewsBeep #News #Headlines #Anthocyanidin #Cellbiology #Chemicalbiology #Fam222B #Geneticscreening #HumanitiesandSocialSciences #Latvia #LV #MicroRNA #multidisciplinary #Science
https://www.newsbeep.com/53145/

Cytology and GeneticsJul 31, 2025
Creation and Application of Liposomal Form of MicroRNA for the Treatment of Neurodenegratative Diseases - #nondegenerativediseases #Alzheimer’sdisease #therapeuticagents #microRNA #delivery #liposomes #genetics - https://link.springer.com/article/10.3103/S0095452725020094
Creation and Application of Liposomal Form of MicroRNA for the Treatment of Neurodenegratative Diseases - Cytology and Genetics

Abstract Targeted delivery of active pharmaceutical ingredients, such as microRNAs, is a pressing issue. The use of liposomes as targeted carriers of various therapeutic agents has certain advantages and is currently growing significantly. Liposomes are capable of transporting both hydrophilic and hydrophobic molecules simultaneously. Liposomes have relatively high stability under physiological conditions and controlled release of encapsulated ingredients, and are biocompatible with cell membranes. Liposome-encapsulated microRNA-based drugs may become a certain alternative to classical therapeutic agents in the treatment of neurodegenerative diseases. Neuroinflammation is known to be mediated through complex interactions between cells of the central nervous system (CNS) and the periphery. Although the inflammatory response in the healthy brain is tightly controlled by numerous regulatory mechanisms, deregulation can occur in these processes under pathological conditions. Such deregulation leads to uncontrolled neuroinflammation. Among the main regulators of these processes, microRNAs play an important role. Due to miRNAs, processes can become deregulated, contributing to disease progression, or may reflect a homeostatic attempt by the CNS to prevent excessive damage and restore normal functioning conditions. The paper summarizes the literature data on the creation, properties, and application of the liposomal form of miRNA, in particular msiRNA-101, in the development of Alzheimer’s disease.

SpringerLink
HusnainJun 11, 2025

🚨 Our Frontiers in Molecular Neuroscience review explores how microRNAs (miRNAs) could transform early diagnosis of neurodegenerative diseases 🧠

🧬 Also covers aging & protein PTMs!
📖 https://doi.org/10.3389/fnmol.2024.1386735
#Neuroscience #microRNA #Neurodegeneration #Biomarkers #Alzheimers #OpenScience

HusnainApr 20, 2025

🧠 Exciting News! Our review article is published!
We explore how miRNAs could enhance diagnostics and their role in PTM and Aging 🧠🧬
🔗https://doi.org/10.3389/fnmol.2024.1386735
🔗 https://go.nature.com/3FSQrke

#MicroRNA #Neurodegeneration #PostTranslationalModifications #AgingAndDisease #MolecularNeuroscience #RNARegulation #GeneExpression #Biomarkers #EarlyDiagnosis #FrontiersInNeuroscience #ScientificResearch #BTU #Charite #DZNE #BrainHealth #Epigenetics #NextGenDiagnostics #Neurobiology #miRNABasedDiagnostics

Frontiers | MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review

Neurodegenerative diseases (ND) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leadin...

Frontiers
John Vaccaro (johniac)Feb 28, 2025

SciTech Chronicles. . . . . . . . .Feb 28, 2025

https://bit.ly/stc022825

#corn #earworm #flavonoids #microbiome ##Quantum-computing #linking #connectivity #12-qubit ##Vesuvius #brain #X-rays #vitrification #microbes #modules #free-living #ecosystem #bamboo #microRNA #feeding #regulators

SciTech Chronicles. . . . . . . . .Feb 28th, 2025

Some make amends... Some make a wound. Vol II No 53 315 links Curated flavonoidcompounds have an insecticidal effect on corn earworm larvae....