Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation.
This study uncovers a mechanism of rice heading regulation mediated by circular RNAs (ciMIR156Ds) derived from pri-miR156d that refine the aging-dependent expression of miR156 through R-loop formation.
TLDR: Pandas are dope fiends!?
TIL that 🐼 Pandas aren't born loving 🎍bamboo, but that it's an addiction with a dopamine component.
Those cute furry pandas are actually carnivores. 🍖
But they sit on their butts all day eating plants 🌿 and getting 🌀👃🌀 high instead of chasing animals. 🐁
Quote: "some of the bamboo-derived miRNAs were found to regulate dopamine pathways, driving food motivation and the reward system linked to it. So if eating bamboo is a pleasurable, satisfying experience for a panda, it's more likely to be solely driven to seek out this trigger." https://newatlas.com/biology/pandas-bamboo-micro-rna/
Pandas! 
Built to be carnivorous, giant pandas spend up to 16 hours a day on their backsides eating bamboo. But contrary to all the panda jokes, it's not because they're lazy or too dumb to know better. It's far more fascinating – and it may help humans, too.
Why don't #pandas eat more meat? #Molecules found in #bamboo may be behind their plant-based diet.
#miRNA #regulation #gene_expression #sensing #dopamine
https://phys.org/news/2025-02-dont-pandas-meat-molecules-bamboo.html
Giant pandas have digestive systems that are typical for carnivores. Yet, bamboo is their main source of food. They have evolved several features; for example, pseudo thumbs to grasp bamboo and flat teeth that are well suited for crushing it, that make it possible for them to live off plants.
The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers
https://www.science.org/doi/10.1126/sciadv.ado2830
pdf: https://www.science.org/doi/epdf/10.1126/sciadv.ado2830
* diverse regulatory roles in cancer
#cancer #genetics #genomics #FunctionalGenomics #NoncodingDNA #ncDNA #miRNA #GeneRegulation #CRISPR
To achieve this, we developed #DynamiR (https://codeberg.org/a_probst/DynamiR).
DynamiR a Python-based open-source tool with minimal dependencies, making it easy for anyone to analyze independently.
It's built on open data and decentralized, ensuring flexibility and adaptability.
#miRNA #NeurodegenerativeDiseases #ResearchUpdates #OpenScience #SoftwareDevelopment #PD #ALS #HD
research article [2019]
Pollen-derived RNAs Are Found in the Human Circulation
https://doi.org/10.1016/j.isci.2019.08.035
#pollen #microRNA #miRNA #bioavailability #platelets #Lungs #biology
Cancer vaccines show promise
https://www.economist.com/science-and-technology/2025/01/01/cancer-vaccines-are-showing-promise-at-last
non-paywalled: https://archive.fo/ncAYX
Comment: revolutionary
* trials: skin, brain, lung tumors
* possible w/i 6 wk due to mRNA vaccines
https://en.wikipedia.org/wiki/MRNA_vaccine
* uses fragment (cloned copy) of messenger RNA (mRNA)
* injected; stimulates adaptive immune response
* body identifies/destroys corresponding pathogen (SARS-Cov-2: COVID-19 ...) or cancer cells
#cancer #cancervaccines #vaccines #mRNA #mRNAvaccines #immunity #ImmunoTherapy #miRNA
Andrew M. Lewis, Jr & Gladys S. Lewis on #PLOSONE October 24, 2022
The AGMK1-9T7 cell model of #neoplasia: Evolution of #DNA copy-number aberrations and #miRNA expression during transition from normal to #metastatic #cancer cells
To study neoplasia in tissue culture, cell lines representing the evolution of normal cells to tumor cells are needed. To produce such cells, we developed the AGMK1-9T7 cell line, established cell banks at 10-passage intervals, and characterized their biological properties. Here we examine the evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40. We demonstrated the use of a human microarray platform for DNA copy-number profiling of AGMK1-9T7 cells using knowledge of synteny to ‘recode’ data from human chromosome coordinates to those of the African green monkey. This approach revealed the accumulation of DNA copy-number gains and losses in AGMK1-9T7 cells from passage 3 to passage 40, which spans the period in which neoplastic transformation occurred. These alterations occurred in the sequences of genes regulating DNA copy-number imbalance of several genes that regulate endothelial cell angiogenesis, survival, migration, and proliferation. Regarding miRNA expression, 195 miRNAs were up- or down-regulated at passage 1 at levels that appear to be biologically relevant (i.e., log2 fold change >2.0 (q<0.05)). At passage 10, the number of up/down-regulated miRNAs fell to 63; this number increased to 93 at passage 40. Principal-component analysis grouped these miRNAs into 3 clusters; miRNAs in sub-clusters of these groups could be correlated with initiation, promotion, and progression, stages that have been described for neoplastic development. Thirty-four of the AGMK1-9T7 miRNAs have been associated with these stages in human cancer. Based on these data, we propose that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro.
E anche oggi abbiamo certificato l'ignoranza dei no-vax, gruppo di dementi molto nutrito e anche molto rumoroso in Italia.
Perché dico questo? Perché alla notizia della vittoria del Nobel per la medicina da parte di Victor Ambros e Gary Ruvkun per il loro lavoro sul microRNA, i no-vax hanno iniziato a parlare lobby, vaccini per covid , BigPharma etc senza sapere che il microRNA è un acido nucleico diverso dal mRNa
#miRNA #mRNA #AcidoNucleico #biologia #nobelmedicina2024
https://www.lescienze.it/news/2024/10/07/news/nobel_medicina_fisiologia_2024-17354060/
Amelia Cervera 🧬
datum (n=1)
CellBioNews
Victoria Stuart 🇨🇦 🏳️⚧️
RoedigerRG
Rhyothemis
T. Reid Lewis
Marco 
Michaela Maya