@mzdravkov we've observed that in all runs, usually a few % of reads, sometimes over 10%. When you plot raw signals, you'll see strange stretches similar to homopolymer... we haven't observe anything like this in rna002, only in rna004.
my working hypothesis it that's because of helicase #stalling specific to new #RNA #helicase variant used in #rna004
@nanopore

This is it. This is home.

Out of all the Universe, this is the one place we can call ours, and not just ours. It belongs to every living thing that came to be on it.

This is our Heaven, if we treat it like it is.

#Space #ReligiousNaturalism #ReligiousNaturalist #RNA #Earth #Artemis #Artemis2

RNA Book of the Month

The Light Eaters by Zoë Schlanger

The Light Eaters is a deep immersion into the drama of green life and the complexity of this wild and awe-inspiring world that challenges our very understanding of agency, consciousness, and intelligence. In this captivating exploration of plant intelligence, we see that plants, rather than imitate human intelligence, have perhaps formed a parallel system.

#RNA #ReligiousNaturalism #ReligiousNaturalist #Bookstodon

⚛️ Can we design drugs that stabilize biomolecular interactions instead of blocking them?

🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0016

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign #SystemsBiology #MedicinalChemistry

Health

A Simple Injection Could Help the Heart Heal Itself After a Heart Attack

A new RNA-based therapy aims to address one of cardiology’s most persistent challenges: the heart’s inability to regenerate after injury.

SciTechDaily
“Non-coding RNAs turn out to regulate everything from embryonic development to immune responses to brain function. They help determine which genes get turned on and off, and when. They can promote cancer or suppress it.”
#Science #Scicomm #RNA #Medicine #DevBio
https://knowablemagazine.org/content/article/living-world/2026/noncoding-rna-molecules-in-cells
The silent majority: RNAs that don’t make proteins

Once considered cellular junk, non-coding RNAs are emerging as key players in everything from brain development to cancer — with much still to be discovered

Knowable Magazine | Annual Reviews
States

What if tiny “sticky notes” on #RNA could help us understand disease? 🧬

The EU-funded ROPES project explores how chemical tags on RNA influence protein production and health, opening new paths for detection, diagnosis and treatment.

🎥 link.europa.eu/XnrDMw

#RNA

Video
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https://nitter.net/CORDIS_EU/status/2032464312124768325#m

`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`

https://doi.org/10.1038/s41467-026-69642-3

#splicing #RNA #genetics #exon #assay