🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
A coordinated recruitment of actin and myosin at large vesicles allows for the "exocytosis by vesicle crumpling" in Drosophila larval salivary glands.
Inès Jmel Boyer covers a preprint from Kumari Kamalesh & team which describes a mechanism that requires precise spatiotemporal control of actomyosin contractility.
#preLight 👉 https://prelights.biologists.com/highlights/structured-rhogef-recruitment-drives-myosin-ii-organization-on-large-exocytotic-vesicles-v2/
#CellBiology #CellMembrane #biomechanics #exocytosis #vesicles #actin #myosin
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Fabrizio Musacchio
preLights
Stephen Royle
Mary Munson
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