Rxiv mechanobio1h ago
📰 "Wide-field NV magnetometry under simultaneous high-pressure and high-temperature conditions"
https://arxiv.org/abs/2606.25378 #Cond-Mat.Mtrl-Sci #Physics.App-Ph #Quant-Ph #Pressure #Cell
Wide-field NV magnetometry under simultaneous high-pressure and high-temperature conditions

We demonstrate wide-field optically detected magnetic resonance (ODMR) under simultaneous high-pressure and high-temperature conditions using nitrogen-vacancy (NV) centers. Although NV-center magnetometry has been widely used for spatially resolved magnetic-field imaging, its application to extreme environments combining pressure and temperature remains challenging. In this work, we show that ODMR can be observed at 5 GPa and 500 K, demonstrating the feasibility of NV spin readout under such combined extreme conditions. We further perform wide-field ODMR of iron at 7 GPa and 500 K, where the stray magnetic field from the sample is spatially visualized through the pressure cell. These results establish NV-center magnetometry as a promising platform for imaging magnetic phenomena in materials under high-pressure and high-temperature environments.

arXiv.org
Rxiv mechanobio1h ago
📰 "Dynamic masking for boundary-aware velocity reconstruction in volumetric particle tracking with moving solids"
https://arxiv.org/abs/2606.25748 #Physics.Flu-Dyn #Pressure #Cell
Dynamic masking for boundary-aware velocity reconstruction in volumetric particle tracking with moving solids

Volumetric particle tracking velocimetry (PTV) produces scattered Lagrangian tracks that must be reconstructed on an Eulerian grid before velocity gradients, pressure, or hydrodynamic loads can be evaluated. This step is usually performed on a domain treated as entirely fluid. When a solid body lies within the measurement volume, its surface kinematics are not imposed and the reconstruction is weakest in the steep-gradient region next to the body. We introduce LE-DM (Lagrangian-to-Eulerian reconstruction with Dynamic Masking), a constrained reconstruction framework for moving solid boundaries. A time-dependent signed-distance function classifies grid nodes as open fluid, boundary shell, or solid interior. The particle data, incompressibility constraint, prescribed surface velocity, and regularization terms are then assembled on the masked domain within a single solve. The method requires only a signed-distance field and a surface velocity, allowing stationary walls, translating, rotating, multiple, and deforming bodies to be represented in the same formulation. LE-DM is assessed using an analytical oscillating sphere, synthetic tracks from a CFD rising-sphere simulation, and a refractive-index-matched tomographic-PTV experiment on a freely rising sphere. The surface kinematics are enforced to solver tolerance, while the bulk reconstruction remains unchanged where no body is present. In the analytical case, the first-cell error is reduced from 14\% to 3\% of the body speed. In the experiment, LE-DM recovers the independently measured surface velocity, whereas an all-fluid reconstruction does not. The result is a divergence-free, boundary-consistent velocity field for pressure and force estimation.

arXiv.org
Rxiv mechanobio7h ago
📰 "Adaptive mechanochemical mechanisms of the nucleus during confined cell migration"
https://doi.org/doi:10.1073/pnas.2604716123
https://pubmed.ncbi.nlm.nih.gov/42341039/
#CellMigration #Cell
Rxiv mechanobio7h ago
📰 "A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis"
https://doi.org/doi:10.1073/pnas.2528001123
https://pubmed.ncbi.nlm.nih.gov/42341038/
#Morphogenesis #CellDivision #Cell
Rxiv mechanobio7h ago
📰 "Obligatory intracellular bacterium Anaplasma phagocytophilum AnkA regulates actin dynamics and spatiotemporal bacterial release"
https://doi.org/doi:10.1371/journal.ppat.1014350
https://pubmed.ncbi.nlm.nih.gov/42340982/
#Dynamics #Actin #Cell
Obligatory intracellular bacterium Anaplasma phagocytophilum AnkA regulates actin dynamics and spatiotemporal bacterial release

Author summary While cortical cytoskeleton serves as a barrier for exocytosis, how exocytic release of intra-vacuolar bacteria occurs through this barrier is poorly understood. Using obligatory intravacuolar bacteria Anaplasma phagocytophilum as a model, this study revealed it actively regulates exocytic bacterial release by deploying a type IV secretion effector, AnkA. Abundant AnkA is progressively secreted during bacterial growth and colocalized with cortical actin filaments. AnkA was found to interact with actin and actin regulatory proteins α-actinin 4 and gelsolin, thereby coordinated bacterial growth, cortical actin remodeling, and bacterial exocytosis. Sustained retention of A. phagocytophilum in nutritious intracellular niche is essential for bacterial replication, and timely extracellular release prior to demise of infected host cells is required for bacterial spreading for survival. This study revealed remarkable adaptation in obligatory intravacuolar pathogen by evolving a unique AnkA protein, providing a new paradigm of microbial pathogenesis by manipulation of spatiotemporal actin dynamics by a bacterial molecule.

Rxiv mechanobio13h ago
📰 "GhTTLL12 Coordinates With Transcriptional Regulators GhMML3 and GhMYB86 to Orchestrate Cotton Fibre Development Through Modulating Microtubule Dynamics"
https://doi.org/doi:10.1111/pbi.70706
https://pubmed.ncbi.nlm.nih.gov/42340148/
#CellDivision #Microtubule #Dynamics #Cell
Rxiv mechanobio13h ago
📰 "Force-Locking DNA Hairpin Probes for High-Throughput and Cumulative Detection of Intercellular Molecular Tensions"
https://doi.org/doi:10.1002/anie.6632525
https://pubmed.ncbi.nlm.nih.gov/42340164/
#Mechanical #Force #Cell
Rxiv mechanobio13h ago
📰 "Implications of Rho GTPase signaling in cancer immunotherapy"
https://doi.org/doi:10.1042/BST20260485
https://pubmed.ncbi.nlm.nih.gov/42339915/
#Dynamics #Cell
Rxiv mechanobio1d ago
📰 "Emetine dihydrochloride suppresses the invasiveness and motility of hepatocellular carcinoma cells through MAPK pathway inhibition and Twist1 protein destabilization"
https://doi.org/doi:10.1038/s41598-026-59002-y
https://pubmed.ncbi.nlm.nih.gov/42337289/
#CellMigration #Cell
Rxiv mechanobio1d ago
📰 "Fiber Density-Driven Mechanotransduction Reconstructs Collagen Heterogeneity in the Annulus Fibrosus"
https://doi.org/doi:10.1016/j.actbio.2026.06.043
https://pubmed.ncbi.nlm.nih.gov/42336343/
#Mechanotransduction #Mechanical #Cell