The “full collapse vs kiss-and-run” debate for synaptic vesicle fusion dates back to the 1970s. In the last 10 years ultrafast endocytosis was proposed as a reconciliation. A paper out in Science today describes “Kiss-shrink-run” and hyperfast recycling…

Their observation of vesicles that shrink upon exocytosis is cool and the technology that enabled this cryoET is very impressive. As for resolving any debate - let's see.

https://www.science.org/doi/10.1126/science.ads7954

#CellBiology #MembraneTraffic #Neuroscience

^ if this paper is of interest. There's a related preprint from van der Groot, Dal Peraro and D’Angelo labs:

https://www.biorxiv.org/content/10.1101/2025.06.26.661665v1

#MembraneTraffic #structbio

This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport.

The mechanistic basis of cargo selection during Golgi maturation

Taylor, Zubkov, Ciazynska et al.

https://doi.org/10.1101/2025.06.26.661719

#MembraneTraffic #structbio

Gabrielle is giving a talk today in the Warwick SLS-WMS Postdoc Association Seminar Series.

"Hacking the logic of clathrin-coated vesicle creation”

10 am in A1.51, Gibbet Hill

#CellBiology #MembraneTraffic

A riddle for Golgi Day: how many Golgis can you spot in this photo? #membranetraffic #CellBiology
I’m currently looking for a post-doc in the UK, particularly to work on projects that employ in-vitro reconstitution and quantitative #microscopy approaches to study #cellbiology processes (esspecially #membranetraffic) + would be grateful for sign-posting towards openings! 🙏 #academicchatter
We received this payment card protector to incentivise us to take part in an Office for National Statistics Crime survey.
I said, ‘ah they’ve used the classic Biorender concentric-ring endoplasmic reticulum icon as their logo.’
My partner responded, ‘I think that’s meant to be a finger print because it talks about protecting your identity.’
Only the real ones would understand… #CellBiology #membranetraffic

EMBO Workshop
From molecules to organisms: An integrative view of cell biology
16 – 21 March 2025 | Radstadt, Austria

Organised by Sharon Tooze and Marino Zerial
Deadline is 1st Dec
https://meetings.embo.org/event/25-cell-bio

#CellBiology #MembraneTraffic

From molecules to organisms: An integrative view of cell biology

This EMBO Workshop follows the enthusiastic response to the conference organized in 2017. It responds to the need to revisit the structural and functional organization of cells in order incorporate a…

And now for some new News!

This week we welcomed Anneline Moret to our lab. Anneline is a EUTOPIA co-tutelle student between our lab and Paris Cergy University. She'll be working on engineered membrane traffic of integrin in a cancer context.

#CellBiology #MembraneTraffic