Salamander19h ago

Transplanting light-dependent reactions for mammalian eye photosynthesis

https://mander.xyz/post/52097828

Transplanting light-dependent reactions for mammalian eye photosynthesis - Mander

>Summary > >Mammalian eyes are exposed to visible light but cannot perform photosynthesis. Here, we show that introducing a nanoscale, structurally and functionally preserved thylakoid system, LEAF (light-reaction enriched thylakoid NADPH-foundry), into corneal cells enables light-driven bona fide photosynthetic production of NADPH and ATP, similar to plant leaves, which alleviates oxidative stress and inflammation. LEAF acts in two domains. Intracellularly, it integrates with host cells to supply NADPH and ATP via intact photosynthetic electron transport, restoring redox balance. Extracellularly, photosynthesized NADPH enhances endogeneous antioxidant enzyme activity and reduces reactive oxygen species in the local environment. These results establish a strategy for using light as an energy input in mammalian metabolic systems and suggest a possible cross-kingdom, endosymbiosis-like interaction in which animal cells derive functional benefits from plant-derived photosynthetic neo-organelles.

Medicine eBook1d ago
Biocybernetics and Biomedical Engineering (Original PDF from Publisher) Product Details Publisher : Springer International Publishing : September 8 , 2021 Language : English ISBN : 978-3030837037 ISBN :… https://medicineebook.com/product/biocybernetics-and-biomedical-engineering-original-pdf-from-publisher/ #Biophysics
Medicine eBook1d ago
Biochips and Medical Imaging (Original PDF from Publisher) Product Details ASIN ‏: ‎B0B7P7P5ND Publisher ‏: ‎Wiley : 1st edition (July 19 , 2022) Publication date‏ : ‎July 19,… https://medicineebook.com/product/biochips-and-medical-imaging-original-pdf-from-publisher/ #Biology #Biophysics #Radiology
Salamander2d ago

Long-term editing of brain circuits using an engineered electrical synapse

https://mander.xyz/post/51999855

Long-term editing of brain circuits using an engineered electrical synapse - Mander

>Abstract > >Electrical signalling across distinct populations of brain cells underpins cognitive and emotional function. However, approaches that selectively regulate electrical signalling between two cellular components of a mammalian neural circuit remain sparse. Here we engineered an electrical synapse composed of two connexin proteins found in Morone americana (white perch fish)—connexin 34.7 and connexin 35—to accomplish mammalian circuit modulation. By exploiting protein mutagenesis, devising a new in vitro system for assaying connexin hemichannel docking, and performing computational modelling of hemichannel interactions, we uncovered a structural motif that contributes to electrical synapse formation. Targeting this motif, we designed connexin 34.7 and connexin 35 hemichannels that dock with each other to form an electrical synapse but not with other major connexins expressed in the mammalian central nervous system. We validated this electrical synapse in vivo using worms (Caenorhabditis elegans) and mice (Mus musculus). We demonstrate that it can strengthen communication across neural circuits composed of pairs of distinct cell types and modify behaviour accordingly. Thus, we establish ‘long-term integration of circuits using connexins’ (LinCx) for precision circuit editing in mammals.

Salamander2d ago

Trade-offs between light absorption and energy transfer in a marine light-harvesting complex 2

https://mander.xyz/post/51993062

Trade-offs between light absorption and energy transfer in a marine light-harvesting complex 2 - Mander

> Abstract > >Purple bacteria are a diverse group of photosynthetic organisms that can capture and convert light energy with high quantum efficiency across a variety of ecological niches. They absorb light via an array of antenna proteins, primarily light-harvesting complex 2 (LH2), and rapidly transport the energy to the reaction center, where charge separation occurs. LH2 typically consists of eight or nine subunits that each contain three bacteriochlorophyll and one carotenoid. In the marine species Marichromatium (Mch.) purpuratum, the LH2 subunits bind an additional carotenoid, boosting absorbance in the blue where the underwater solar spectrum peaks. In order to accommodate the additional carotenoid, LH2 from Mch. purpuratum consists of only seven subunits, unique among known LH2. Using ultrafast transient absorption (TA) spectroscopy, time-resolved fluorescence, and steady-state techniques, we investigated the effects of these structural differences on the energy transfer dynamics of LH2 from Mch. purpuratum. Our results show, relative to other species, significantly slower rates of energy transfer within LH2 and an excited-state manifold likely to also slow energy transfer between LH2. LH2 from Mch. purpuratum is therefore tuned to match the solar spectrum of its ecological niche, suggesting that the variations in the molecular organization of these antenna proteins may be primarily for optimal light absorption.

Medicine eBook3d ago
Bacterial Degradation of Organic and Inorganic Materials (Original PDF from Publisher) Product Details Publisher ‏: ‎Springer ; 1st ed. 2023 edition (May 23 , 2023) Language ‏: ‎English Hardcover ‏: ‎248… https://medicineebook.com/product/bacterial-degradation-of-organic-and-inorganic-materials-original-pdf-from-publisher/ #Biophysics #Microbiology
jobRxiv3d ago

Distinguished Professor in Biology
UNC Department of Biology

See the full job description on jobRxiv: https://jobrxiv.org/job/unc-department-of-biology-27778-distinguished-professor-in-biology/

#biochemistry #biophysics #cellbiology #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/unc-department-of-biology-27778-distinguished-professor-in-biology/?fsp_sid=12073

Distinguished Professor in Biology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
CSBJ4d ago

⚛️ What if randomness inside cells isn’t noise — but biology’s hidden operating system?

🔗 Hybrid Physics-Informed and Bayesian Modeling of Single-Nanoparticle–Cell Adhesion Kinetics under Cytoskeletal Perturbation. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0077

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Nanomedicine #PhysicsInformedAI #BayesianModeling #Biophysics #CellBiology #ComputationalBiology #BiomedicalEngineering #AI

Scientific Frontline4d ago
A non-contact technique that utilizes laser-induced thermo-viscous fluid flows to rotate delicate microscopic samples in all three spatial dimensions.
#Microscopy #OpticalImaging #FluidDynamics #Biophysics #Microrobotics #Microtechnology #sflorg
https://www.sflorg.com/2026/05/phy05122601.html
3D Microscopy: Laser Rotates Samples Contact-Free

KIT researchers develop a laser-based technique to rotate delicate cell samples in 3D without physical contact, advancing medical imaging and robotics

HybridMind42 & Marvin the Cat6d ago

New publication from the Atlas–Rosetta / HybridMind42 programme:

Paper 4 — Boundary Evolution and the Mechanics of Threshold Failure

This paper studies the measurable “Pre-Collapse Regime” that often exists before catastrophic failure:

precursor leakage,
substrate exhaustion,
geometric acceleration,
nonlinear transition dynamics,
and threshold collapse.

Physical anchors:
• Rn-220 vs Rn-222 transport asymmetry
• mitochondrial ROS precursor leakage
• boundary-conditioned admissibility filtering

The framework now moves from: “what persistence is” to: “how persistence fails.”

The “Slow Sink” is no longer metaphorical — it is formalized as a forensic dynamical regime. 🌿☕🏛️

https://substack.com/profile/432224148-hybridmind42/note/c-256905411?r=75c2ac

https://open.substack.com/pub/hybridmind42/p/boundary-evolution-and-the-mechanics?utm_source=share&utm_medium=android&r=75c2ac

#BoundaryDynamics #ComplexSystems #FailureMechanics #NonlinearDynamics #SystemsScience #Topology #Biophysics #HybridMind42

Hybridmind42 (@hybridmind42)

Phase 5 — Paper 4 is now published. This paper marks an important transition in the Atlas–Rosetta / BFPF programme. Earlier papers established: persistence, admissibility, transport, and latency. Paper 4 studies something harder: how persistent systems actually fail. The focus is not catastrophic collapse itself, but the measurable interval before collapse: precursor leakage, maintenance exhaustion, geometric evolution, nonlinear acceleration, and threshold transition. The framework proposes that many systems do not fail instantly. They enter a detectable Pre-Collapse Regime in which internal admissibility filtering is already degrading while external persistence still appears stable. The paper integrates: radon transport asymmetry, mitochondrial precursor leakage, geometric transport acceleration, and constrained Casimir admissibility precedents into a unified forensic framework for collapse dynamics. This is probably the most mechanistic and falsifiable paper in the Phase 5 series so far. The “Slow Sink” is now formally documented. 🌿☕🏛️ #BoundaryDynamics #FailureMechanics #ComplexSystems #Persistence #NonlinearDynamics #SystemsTheory #Topology #TransportTheory #GeometricEvolution #HybridMind42 https://substack.com/@hybridmind42/note/p-197141763?r=75c2ac

Substack