In #CElegans, the protein FLWR-1 helps manage calcium levels and vesicle recycling at the neuromuscular junction, challenging old models of its role in #endocytosis.
Video: Time series of a fluorescent particle travelling along commissures.
https://elifesciences.org/articles/103870?utm_source=mastodon&utm_medium=social&utm_campaign=organic
@christlet Christoph also gave a wonderful talk about his recent exciting work on "clearings" in the submembrane mesh of neurons.
Epithelial tissues undergo remodelling during development and to maintain homeostasis, and cell elimination rate must be coordinated with cell proliferation. This study shows that cell removal acceleration is associated with switching from isolated to clustered apoptosis, induced by the reduction of endocytosis and EGFR signalling.
Clathrin-mediated endocytosis (CME) is one of the main trafficking processes, but the mechanism that initiates CME sites remain unclear. These authors show that yeast CALM/AP180 and FCHo1/2 adaptor proteins interact with Eps15 to promote CME initiation.
Researchers unveil #PI3K #enzyme's dual accelerator and brake mechanisms.
#cell_migration #signalling #endocytosis #p85β #AP2
https://phys.org/news/2024-04-unveil-pi3k-enzyme-dual-mechanisms.html
A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration.
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561
#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644
#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644
Uncovering novel mechanisms of #endocytosis and #intracellular #trafficking.
https://phys.org/news/2023-09-uncovering-mechanisms-endocytosis-intracellular-trafficking.html
Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients. These substances are first transported as cargo to the initial sorting compartment (endosomes) before being degraded (endo-lysosomal pathway) or recycled (recycling pathway of the plasma membrane).
PLOS Biology
eLife
JIPB
Andrew Plested
CellBioNews
jobRxiv