`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

#Autism, #Neurology, and the Idea of #Cognitive Symmetry

Chris in TX presents "cognitive symmetry," linking #neuronal functions to #spirituality and group dynamics. Ben notes the speculation crosses neurology and #psychology, needing more evidence before scaling mechanisms to #consciousness. Richard recommends authors (Antonio Damasio, Dean Burnett) to help formalize his ideas.

https://www.youtube.com/watch?v=SPl3_y81AL0

#atheist #atheism #health #science

🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.

🌍 https://doi.org/10.1101/2025.09.17.676728

#Neuroscience

From the #brain to the #mind – How does #consciousness arise from #neuronal #structures?

Dr. Sascha Benjamin Fink talks about #neuronal #correlates (#NCC2.0) and how #AI & #virtualreality are changing our #perception.

An exciting intersection of #philosophy, #neuroscience, and #artificialintelligence!

More: https://open.spotify.com/episode/1SJ0oItHKlk7mOVLupxMjX?si=VcExGicATuya1H_-aaLZ9A

or: https://philosophies.de/index.php/2025/06/22/korrelat-des-bewusstseins/

#Consciousness #Neurophilosophy #AI #VirtualReality #NCC #PhilosophyOfMind #CognitiveNeuroscience #ArtificialConsciousness

The new Center for Structural and Functional #Connectomics (CSFC) will be established on our #Garching #campus with funding of around €69 million. 👏 Focus lies on the comprehensive mapping & analysis of all #neuronal connections in the brain: http://go.tum.de/373567

📷A.Eckert

#Zoomposium with #Sascha #Benjamin #Fink: “The search for the #neuronal #correlate of #consciousness - Part 1”

Let's go in search of the “holy grail of #neuroscience” to possibly discover “the neural correlate of consciousness”. The complete interview is in two parts and the first part of our “search” can be seen on our YouTube channel “Zoomposium” at the following link: https://youtu.be/wb3yQXvYITo

Or more information at: https://philosophies.de/index.php/2025/06/22/korrelat-des-bewusstseins/

#Zoomposium with #Sascha #Benjamin #Fink: “The search for the #neuronal #correlate of #consciousness - Part 1”

Let's go in search of the “holy grail of #neuroscience” to possibly discover “the neural correlate of consciousness”. The complete interview is in two parts and the first part of our “search” can be seen on our YouTube channel “Zoomposium” at the following link: https://youtu.be/wb3yQXvYITo

Or more information at: https://philosophies.de/index.php/2025/06/22/korrelat-des-bewusstseins/

#Zoomposium with #Sascha #Benjamin #Fink: “The search for the #neuronal #correlate of #consciousness - Part 1”

Let's go in search of the “holy grail of #neuroscience” to possibly discover “the neural correlate of consciousness”. The complete interview is in two parts and the first part of our “search” can be seen on our YouTube channel “Zoomposium” at the following link: https://youtu.be/wb3yQXvYITo

Or more information at: https://philosophies.de/index.php/2025/06/22/korrelat-des-bewusstseins/