Here is a strong candidate for the coolest-looking #cryoEM structure of 2026! 🤩

Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity

https://doi.org/10.1038/s41586-026-10255-7

#StructuralBiology

The next #CryoEM Current Practices Webinar speaker will be by Rashmi Panigrahi from Memorial University of Newfoundland, St. John’s, Canada speaking on "Capturing Chromatin Dynamics During the DNA Damage Response" 3/26/2026 at 12 PM ET / 9AM PT

Registration is at no-cost, but sign-up is required: https://us02web.zoom.us/webinar/register/WN_NAkOLFAAT7eNeSt49yOYBg

Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of Medicine

See the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/

#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=10553

In the final talk of #Biochemistry2026, Stefan Raunser gave an exciting overview of his group's research on "Unlocking the secrets of the cytoskeleton and heart muscle".

https://www.annualreviews.org/content/journals/10.1146/annurev-biochem-052521-042909
#Biochemistry #Chemistry #ChemBio #Structure #cryoEM
CC @gdch

How do our muscles work on a molecular scale?

Stefan Raunser gave an inspiring lecture on his group's work at the Max Planck Institute of Molecular Physiology, in which they elucidate this question with a great combination of biochemistry and structural biology.

https://www.annualreviews.org/content/journals/10.1146/annurev-biochem-052521-042909
#Biochemistry #Structure #cryoEM #Chemistry #ChemBio
CC: @gdch, @GDCh_BioChem

How are the receptors in the synapse organized?

Diego Ortiz-López from the Hermann Schindelin group discussed his research at #Biochemistry2026. He talked about the organization of receptors in the inhibitory postsynapse by organization of gephyrin oligomers.

https://www.biorxiv.org/content/10.1101/2025.09.01.673457v1
#Biochemistry #cryoEM #Structure #Synapse #Chemistry #ChemBio
CC: @gdch, @GDCh_BioChem

"Cryo-EM Structures of Higher-Order Gephyrin Oligomers Revealing Principles of Inhibitory Postsynaptic Scaffold Organization"

Diego Ortiz-López from the group of Hermann Schindelin gave an insightful talk on this topic at #Biochemistry2026.

https://www.biorxiv.org/content/10.1101/2025.09.01.673457v1
#cryoEM #Synapse #Neuron #Biochemistry #Chemistry #ChemBio
CC: @gdch

Julia Bartoli gave an insightful talk at #Biochemistry2026 about the topic "A host tRNA Drives Assembly of a Cytoplasmic Viral Transcription Machine".

https://www.nature.com/articles/s41594-025-01653-y
#Biochemistry #cryoEM #Chemistry #ChemBio #tRNA #RNA #Virus
@gdch