Sabine Hossenfelder relates her personal journey figuring out a sugar alcohol was a cause of her long misdiagnosed intestinal distress.
Sugar alcohols are a common ingredient in processed food and even medicines but also show up in natural foods.
https://www.youtube.com/watch?v=K5v61YtDYo4
#sugaralcohol #sorbitol #manitol #intestinaldistress #irritablebowel #ibs #diet #health
It’s nearly John Wick 4 day 😊 I really wish my body could do the cinema (for some films) but I don’t stand a chance, especially with longer films 😩
#Fibromyalgia #JointPain #UnstableJoints #ChronicPain #ChronicIllnesses #IBS #IrritableBowel #IrritableBladder #OAB #OverActiveBladder #Diabetic #ChronicFatigue #BrainFog #FibroFog #Autistic #ADHD #AuDHD #Anxiety #Agoraphobia #MentalHealthDisorders #NotGettingBetter
New from Poland:
The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant
Irritable Bowel Syndrome
Free:
https://www.mdpi.com/2072-6643/15/8/1837
Conclusions: Lowering the TRP* content in a low-FODMAP diet may be useful in treating IBS-D.
#FODMAP #FODMAPs #IBS #IBSD #IrritableBowelSyndrome #IrritableBowel @ibs
*Tryptophan
(1) Background: A low-FODMAP diet is often recommended in the treatment of irritable bowel syndrome, but it does not improve abdominal symptoms in all patients, and an alternative diet is desirable. The purpose of this study was to evaluate the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan (TRP) intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways. (2) Methods: 40 healthy people (Group I, Controls) and 80 patients with IBS-D were included in the study. IBS-D patients were randomly divided into two groups of 40 each (Groups IIA and IIB). In Group IIA, the low-FODMAP diet was recommended, while in Group IIB, the same diet was recommended but with limited TRP intake for 8 weeks. The TRP intake was analyzed with the use of the nutritional calculator. Abdominal complaints were assessed using the Gastrointestinal Symptom Rating Scale (GSRS-IBS), and psychological status was simultaneously determined using two scales: the Hamilton Anxiety Scale (HAM-A) and the Hamilton Depression Scale (HAM-D). TRP and its metabolites: 5-hydoxyindoleacetic acid (5-HIAA), kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QA) were measured in urine using liquid chromatography tandem mass spectrometry (LC-MS/MS). (3) Results: The consumption of TRP per mg/kg/b.w./24 h has decreased in Group IIA from 20.9 ± 2.39 to 17.45 ± 2.41 (16.5%) and in Group IIB from 21.3 ± 2.33 to 14.32 (34.4%). Significantly greater improvement was found after nutritional treatment in patients in Group IIB as compared to Group IIA (GSRS score: 38.1% vs. 49.8%; HAM-A: 38.7% vs. 49.9%; HAM-D: 13.8% vs. 35.0%; p < 0.01). Reducing TRP intake showed a negative correlation with the degree of improvement in the GSRS score. (4) Conclusions: Lowering the TRP content in a low-FODMAP diet may be useful in treating IBS-D.
"The effect of melatonin on #IrritableBowelSyndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study"
"#Melatonin can be considered an effective treatment for improving #IBS score, #GI symptoms, & quality of life in IBS patients with & without sleep disorders. It is also effective to improve sleep parameters in IBS patients with sleep disorders"
Free:
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02760-0
Trial uses a high dose of melatonin
Background Irritable bowel syndrome (IBS) is one of the world's most common gastrointestinal (GI) disorders, and current treatments do not meet patients' demands. This study aimed to investigate melatonin's therapeutic effects on IBS score, GI symptoms, quality of life, and sleep parameters in both groups of IBS patients with and without sleep disorders. Methods In this randomized double-blinded placebo-controlled trial study, 136 patients with a diagnosis of IBS based on ROME IV criteria were enrolled and then divided into two groups respecting having sleep disorders or not. Patients of each group were randomized in a 1:1 ratio to receive melatonin 6 mg daily (3 mg fasting and 3 mg at bedtime) for 2 months (8 weeks). Blocked randomization was used in this process. All patients were evaluated both at the beginning and the end of the trial regarding IBS score, GI symptoms, quality of life, and sleep parameters through valid questionnaires. Results In both groups of patients with and without sleep disorders, a significant improvement was observed in IBS score and GI symptoms, including the severity and the frequency of abdominal pain, the severity of abdominal bloating, satisfaction with bowel habits, disease's impact on patient's life, and stool consistency; however, there was no significant improvement in the frequency of defecations per week. In patients with sleep disorders, significant improvement in sleep parameters, including subjective sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction, was observed, while in patients without sleep disorders, there was no significant improvement in sleep parameters. In addition, quality-of-life improvement was observed in a significant number of melatonin recipients compared to placebo in both groups of patients. Conclusion Melatonin can be considered an effective treatment for improving IBS score, GI symptoms, and quality of life in IBS patients with and without sleep disorders. It is also effective to improve sleep parameters in IBS patients with sleep disorders. Trial registration This study has been registered to the Iranian Registry of Clinical Trials (IRCT) with the approval number IRCT20220104053626N2 on the date of 13/02/2022.
Tomorrow is #WorldIBSDay
I wish when I was diagnosed with #IrritableBowelSyndrome the gastroenterologist had been on the look out for #MyalgicEncephalomyelitis which I had all the symptoms of at that time & is often comorbid. It would likely have helped prevent my health deteriorating
#MEcfs #CFS @ibs @mecfs @cfs #IrritableBowel #IrritableBowelSyndrome #ChronicFatigueSyndrome #MEcfs #CFS #MyalgicE #PwME #MEeps #CFSME #CFIDS #SEID #NeuroME
“New Research Links #IrritableBowelSyndrome to Reduced Bacterial Diversity
https://scitechdaily.com/new-research-links-irritable-bowel-syndrome-to-reduced-bacterial-diversity/
“The investigators combined their own dataset with 9 published, shared datasets, encompassing 576 IBS patients and 487 healthy controls”
#IrritableBowel #IBS @ibs #gutmicrobes #gutmicrobiome #gutmicrobiota
According to a team of Korean researchers, individuals with Irritable Bowel Syndrome (IBS) have a decreased diversity of bacteria in their intestines compared to healthy individuals. This is the first study to establish a clear connection between IBS and a reduction in gut microbiota diversity. The
enmodo ⚛️ 🧬 🇺🇦 🍉
Idris (They/Them)
Tom Kindlon