Well from my posts today I seem to have regained some of my cognitive powers today. I didn't struggle through mud to find words or get drained (though that can creep up on me so I need to back off).
It's been just about a year since I've been comfortably able to do that.
I need to keep up the slow pacing and self-restraint. It's taken an uncomfortable amount of doing as little as possible for as long as possible to get to this point.
Highlight from this week's news:
The WE&ME Foundation has launched a new call for ME/CFS research (WE&ME Projects) in collaboration with the Science for ME forum.
They aim to fund 7 projects, each with a budget of €120,000 - 180,000. Researchers from all over the world can apply. The deadline for the first stage is 25 August 2026.
https://www.weandmecfs.org/weme-projects/
They explicitly welcome applications from researchers new to the ME/CFS field
Check out the latest News in Brief (June 15 - 21) from the Science for ME forum, a weekly summary of ME/CFS & Long Covid news including research, advocacy, and coming events.
https://s4me.info/threads/news-in-brief-june-2026.50572/#post-701886
Anyone can read public forum posts but if you become a forum member then you can join the discussion 😁
Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the All of Us Research Program — Kehl-Floberg et al
"there were no significant differences in risk of long COVID based on either pre-infection total incidences of long COVID symptoms (compared to the average of 4) or pre-infection functional impairment."
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0330793
Importance Over seven million U.S. adults experience persistent health issues after COVID-19, known as “long COVID”. Although multiple guidelines recommend the inclusion of functional status in long COVID diagnostic criteria, more evidence is needed to guide this recommendation. This study explored the adjusted odds of developing long COVID by pre-infection symptoms and functional status, and the feasibility of estimating functional status using health records data. Design & Methods Retrospective cohort study of U.S. adults with history of COVID-19 enrolled in a multicenter national cohort study through July 2022 (All of Us Controlled Tier CDR 7.0), using diagnostic, procedure, and billing codes from the health record, and baseline survey responses. The risk of long COVID was estimated using logistic regression by pre-infection (−5 years) incidences of (a) at least one symptom common in long COVID, and (b) functional impairment, and adjusted for disease and demographic characteristics. Results n = 65,464 met inclusion criteria; n = 40,655 had post-infection occurrences of at least one symptom (long COVID group), n = 24,809 had none (recovered). Adjusted odds ratios of developing long COVID increased with older age, female sex, Black racial identity, earlier variant, non-vaccination, lower pre-infection self-reported mental and cognitive health, and number of pre-infection symptoms. Adjusted odds were not significantly affected by any single pre-infection symptom, self-rated physical ability, or EHR-derived indicators of prior functional impairment. Conclusions In this model, there were no significant differences in risk of long COVID based on either pre-infection total incidences of long COVID symptoms (compared to the average of 4) or pre-infection functional impairment. This suggests that long COVID was associated with a change from baseline functioning and health, including in people with pre-infection incident symptoms and functional impairments. The impacts of co-occurring pre-infection symptoms requires further investigation. Both harmonized electronic health records data and patient-reported outcomes contribute important data for developing the diagnostic utility of functional status changes in long COVID.
Umfrage zur Versorgungssituation bei Long Covid und Me/cfs in Berlin.
Gern teilen.
Genetic association between LONG COVID and TMPRSS2 polymorphisms (rs12329760 and rs2070788) in Brazilian healthcare professionals — Telles et al
"carriers of the G allele in this model have an odds ratio of 1.73 times more likely to experience memory and concentration problems." "This result supports the relationship between this polymorphism and the severity of COVID-19 in the acute phase"
Long COVID syndrome has a multifactorial cause that is not fully understood and may be influenced by both external and intrinsic factors. In this context, a ...
Identifying electroencephalography (EEG)-based biomarkers of Long COVID — Sánchez
"Following the [Motor Learning] task, Long COVID individuals exhibited a smaller increase in global efficiency and a larger decrease in participation coefficient relative to healthy controls." "This suggests that the brain's ability to reorganize its network in response to cognitive demands may be a sensitive marker of Long COVID-related fatigue and cognitive impairment."
https://mcgill.scholaris.ca/items/031cf911-4bca-473c-9f37-8b94853c6d55
La COVID longue est une condition marquée par des symptômes persistants tels que la fatigue, les troubles cognitifs et le malaise post-effort (PEM), de plus en plus reconnus comme des conséquences neurologiques de la maladie. Comprendre les bases neuronales de ces symptômes est essentiel pour identifier des biomarqueurs, guider l’évaluation clinique et développer des interventions ciblées. Cette thèse a utilisé l’électroencéphalographie (EEG) à haute densité afin d’examiner la relation entre l’activité cérébrale et les symptômes persistants chez des personnes atteintes de COVID longue, en se concentrant sur l’activité liée au mouvement ainsi qu’au repos. Les analyses ont porté sur les caractéristiques spectrales, les oscillations dans la bande bêta, la connectivité fonctionnelle, les métriques issues de la théorie des graphes (GTA) et la complexité neuronale, afin de caractériser les altérations cérébrales sous-jacentes.Vingt individus atteints de COVID longue et vingt témoins sains appariés en âge et en sexe ont participé à l’étude. Le protocole comprenait des enregistrements de l’activité cérébrale au repos et lors de contractions soutenues de la main, suivis d’une tâche d’apprentissage moteur (ML) destinée à accroître la charge cognitive, puis d’enregistrements post-tâche au repos et lors de contractions de la main.Pour examiner la dynamique oscillatoire du cortex sensorimoteur (SMC), la désynchronisation bêta liée au mouvement (MRBD) et le rebond bêta post-mouvement (PMBR) ont été quantifiés à partir des enregistrements EEG lors des contractions. Ces mesures reflètent respectivement la préparation motrice, l’exécution et l’inhibition après le mouvement. Les propriétés périodiques alpha, associées à l’excitabilité corticale et à l’inhibition fonctionnelle, ont été évaluées à partir des enregistrements EEG au repos avec les yeux ouverts. Les participants COVID longue ont présenté un PMBR significativement réduit ainsi qu’un ralentissement de la fréquence centrale alpha dans le SMC. Un PMBR plus faible était associé à des plaintes cognitives accrues, tandis qu’une fréquence centrale alpha plus lente était associée à une fatigue et à des difficultés cognitives plus marquées.Afin d’approfondir l’investigation de l’ensemble du cerveau, les paramètres spectraux, la connectivité fonctionnelle, les métriques de GTA et les mesures de complexité ont été calculés à partir des enregistrements EEG au repos avec les yeux fermés, réalisés avant et après la tâche ML. Ces analyses renseignent sur l’organisation du cerveau en tant que réseau, l’efficacité de sa communication et la flexibilité de ses signaux. À l’état de base, les participants COVID longue ont montré une largeur de bande alpha significativement plus étroite que celle des témoins. Après la tâche ML, ils ont présenté une augmentation plus faible de l’efficacité globale et une diminution plus marquée du coefficient de participation par rapport aux témoins. Plusieurs des mesures EEG étaient associées aux symptômes et aux performances cognitives, suggérant que la capacité du cerveau à réorganiser son réseau face à une charge cognitive accrue pourrait constituer un marqueur sensible de la fatigue et des troubles cognitifs liés à la COVID longue.En intégrant les résultats à différents niveaux spatiaux et fonctionnels, cette thèse caractérise les patrons d’activité corticale associés à la COVID longue, révélant un ralentissement spectral, une modulation oscillatoire réduite et une reconfiguration altérée du réseau après une charge cognitive. Ces résultats offrent des pistes prometteuses pour l’identification de biomarqueurs EEG de la COVID longue et ouvrent la voie au développement d’interventions thérapeutiques ciblées
Muscle fatigue in patients with severe long COVID: A 2-year follow-up study — Almeida et al
Follow-up of hospitalised patients. "The dissociation between preserved gross morphology and microscopic pathology suggests that advanced imaging and biopsy techniques may be necessary to fully characterize muscle changes in patients with long COVID, though this was beyond the scope of the present study."
Persistent Muscle Dysfunction and Symptom Burden in Post-COVID Syndrome: A Prospective Longitudinal Study — Wunderle et al
"patients exhibited significantly lower Fmean, elevated muscular fatigability (Fatigue Ratio), and reduced recovery capacity compared with matched COVID-19 recovered controls at both [Baseline] and [Followup]." "objective muscle impairments remained largely stable over the six-month observation period"
Background Post-COVID syndrome (PCS) is characterized by persistent heterogeneous symptoms after SARS-CoV-2 infection, yet objective biomarkers for symptom severity and longitudinal disease trajectories remain limited. We aimed to characterize muscle function over time in PCS and exam...
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