Gene Therapy Causes Patient to Grow Alarming Tumor

https://fed.brid.gy/r/https://futurism.com/health-medicine/gene-therapy-tumor

Target: $4000 this week!

The #Vulpibus folks are looking to raise a more significant quantity of currency this next week, to catch up with needs that are piling up fast.

Things from hardware and tools, to paying off loans and bureaucracy, to fuel to keep the Vulpibus moving!

It's expensive being poor in a capitalist society.

Let's put everyone in a better position to survive and thrive! Every donation to the Vulpibus increases the ability for it to be used for:

Living
Developing awesome gene editing tech
Rescuing and helping out fellow homeless, trans, LGBTQ+ and Otherkin and Therian folks in this horrible time
Sharing skills in hackerspace-style workshops and projects.

Please gather monies and donate to:
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Other payment methods may need some arranging due to our current situation.

If you wish to stipulate a specific use for the money and see that use play out, let us know.

#Trans
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Colossal Biosciences Is Making Jurassic Park Look Like a Pitch Deck

Dear Cherubs, Dallas has apparently decided extinction is just a product category. Colossal Biosciences is now a billionaire-level biotech spectacle, with the company saying its latest Series C brought total funding to $615 million and ABC News reporting a roster of celebrity backers that includes Tom Brady, Tiger Woods, Paris Hilton and Peter Jackson. Dallas Innovates also reported that the CIA’s venture arm, In-Q-Tel, invested in Colossal back in 2022.

The result is a company that sounds like it was brainstormed by a film studio, a venture fund and a very committed science teacher. Colossal says it is working on de-extinction projects tied to the woolly mammoth, dodo, thylacine and dire wolf, using gene editing, synthetic biology and related conservation tools. So no, this is not literally Jurassic Park; it is more like Jurassic Park after legal review and a lot of grant money.

THE TEA, BUT WITH MICROPIPETTES

In April, Reuters reported that Colossal announced three genetically engineered wolf pups and called them the world’s first successfully “de-extincted” animals, while outside experts were more cautious and described them as genetically modified gray wolves with added dire-wolf traits. ABC News said Colossal edited gray wolf cells at multiple sites and noted the two species are about 99.5% genetically identical, which is a very impressive number and also a reminder that biology is rude and complicated.

That is the key detail the movie version never pauses for: the company is not dusting off a frozen dinosaur and pressing play. It is using ancient DNA, gene editing and surrogate biology to create something that resembles an extinct species closely enough to trigger headlines, debates and a healthy amount of side-eye. The label “de-extincted” is doing a lot of heavy lifting here.

WHY THE MONEY FLOWS

The money makes more sense when you look at the technology stack. Dallas Innovates reported that In-Q-Tel said its interest in Colossal was “less about the mammoths and more about the capability,” while Colossal’s own materials say the work could scale CRISPR, synthetic biology, artificial wombs and genomic preservation platforms. In other words, the extinct-animal angle is the headline; the platform is the business.

Colossal has also built a pop-culture-friendly halo around the science. Its advisory board page lists Tom Brady and George R.R. Martin among its cultural advisors, which is exactly the kind of sentence that makes the internet stop scrolling for a second. That is the trick here: make de-extinction feel part science, part blockbuster, part meme, and suddenly the cap table looks almost inevitable.

The hot take is simple: this is not a cartoonish clone factory, and it is not pure hype either. It is a very expensive attempt to push gene editing, cloning-adjacent methods and reproductive tech into territory that could one day matter for conservation as much as spectacle. The dinosaurs are still fiction, but the lab bills are extremely real.

Sources list
ABC News — https://abcnews.go.com/US/dire-wolf-revived-biotech-companys-de-extinction-process/story?id=120558562
Reuters — https://www.reuters.com/science/us-company-resurrects-extinct-dire-wolf-or-some-version-it-2025-04-08/
Dallas Innovates — https://dallasinnovates.com/mammoth-interest-the-cia-invests-in-dallas-based-colossal-biosciences/
Colossal Biosciences — https://colossal.com/colossal-secures-200m-to-accelerate-de-extinction-and-genomic-innovation/
Colossal Biosciences — https://colossal.com/advisors/
Wikimedia Commons (Laboratory.jpg) — https://commons.wikimedia.org/wiki/File:Laboratory.jpg

RNA-triggered cell killing with CRISPR-Cas12a2

최근 발견된 CRISPR-Cas12a2는 특정 RNA 인식 시 무차별적인 이중가닥 DNA 절단 활성을 발휘하여 효모와 인간 세포에서 목표 RNA를 발현하는 세포를 선택적으로 제거할 수 있다. Cas12a2는 표적 전사체에 의해 활성화되며, 오프타겟 활성화 없이 세포 사멸을 유도한다. 이를 활용해 인유두종바이러스 감염 세포, 유전자 편집 실패 세포, KRAS의 종양 유발 점 돌연변이 세포를 선택적으로 제거하는 데 성공했다. 기존 Cas9, Cas12a, Cas13 기반 방법들이 진핵세포에서 세포 사멸을 효과적으로 유도하지 못한 한계를 극복하는 새로운 CRISPR 도구로 주목된다.

https://www.nature.com/articles/s41586-026-10466-y

#crispr #cas12a2 #cellkilling #rnatriggered #geneediting

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

✂️ Gene Editing - Apr 2026

• Reni-cel boosts neutrophil engraftment and fetal hemoglobin in β-thalassemia
• Risto-cel shows durable HbF expression and HbS reduction in sickle cell disease
• Electromagnetic field switch enables precise in vivo gene control
• Amino acid lipids enable efficient pulmonary CRISPR delivery

https://pir.sh/qmxdxBvgyp

#GeneEditing #CRISPR

BACTERIAL EDITING TOOLBOX GAINS TRACTION ACROSS SPECIES

Scientists created 'recombitrons' to edit bacterial DNA. This new tool works in 15 different bacteria types, offering a general way to change genes.

#BacterialEditing, #Recombitrons, #GeneEditing, #Microbiology, #ScienceNews

https://newsletter.tf/recombitron-tool-edits-dna-in-15-bacterial-species/

A new DNA editing tool called 'recombitrons' can now change the genes of 15 different types of bacteria, making genetic work easier for scientists.

#BacterialEditing, #Recombitrons, #GeneEditing, #Microbiology, #ScienceNews
https://newsletter.tf/recombitron-tool-edits-dna-in-15-bacterial-species/