New mRNA-based anti-cancer vaccine shows incredible promise in eradicating tumors in mice and shows the path to the future fight against the disease
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The future of ‘personalized’ cancer treatment: Antitumor mRNA-based vaccines
Gastric cancer that metastasizes to the peritoneum, or the lining of the abdominal cavity, has a very poor prognosis and is challenging to treat. Now, a group of researchers has developed mRNA-based vaccines that can target tumor-specific ‘neoantigens.’ In combination with anti-PD1 therapy, these vaccines show high antitumor efficacy against gastric cancer with peritoneal metastasis. This approach can potentially be expanded in order to develop ‘personalized’ cancer vaccines for complicated cancer cases.