Laborjournal8h ago
Myrabello heißt der erste in Europa „gecrisperte“ Weißbüschelaffe. Mit ihm entstand ein #Tiermodell, das die #Therapie menschlicher #Taubheit auf völlig neue Weise erforschbar macht. Petra Neis-Beeckmann erzählt seine Geschichte: https://www.laborjournal.de/editorials/3488.php #CRISPR #Geneediting
sayzard3d ago

RNA-triggered cell killing with CRISPR-Cas12a2

최근 발견된 CRISPR-Cas12a2는 특정 RNA 인식 시 무차별적인 이중가닥 DNA 절단 활성을 발휘하여 효모와 인간 세포에서 목표 RNA를 발현하는 세포를 선택적으로 제거할 수 있다. Cas12a2는 표적 전사체에 의해 활성화되며, 오프타겟 활성화 없이 세포 사멸을 유도한다. 이를 활용해 인유두종바이러스 감염 세포, 유전자 편집 실패 세포, KRAS의 종양 유발 점 돌연변이 세포를 선택적으로 제거하는 데 성공했다. 기존 Cas9, Cas12a, Cas13 기반 방법들이 진핵세포에서 세포 사멸을 효과적으로 유도하지 못한 한계를 극복하는 새로운 CRISPR 도구로 주목된다.

https://www.nature.com/articles/s41586-026-10466-y

#crispr #cas12a2 #cellkilling #rnatriggered #geneediting

RNA-triggered cell killing with CRISPR–Cas12a2 - Nature

Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infected or mutation-bearing cells.

Nature
CSBJ6d ago

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

Summarized Science6d ago

✂️ Gene Editing - Apr 2026

• Reni-cel boosts neutrophil engraftment and fetal hemoglobin in β-thalassemia
• Risto-cel shows durable HbF expression and HbS reduction in sickle cell disease
• Electromagnetic field switch enables precise in vivo gene control
• Amino acid lipids enable efficient pulmonary CRISPR delivery

https://pir.sh/qmxdxBvgyp

#GeneEditing #CRISPR

Gene Editing Research Summary April 2026 - Summarized Science

Summary of key Gene Editing publications highlighting major findings, clinical relevance, and emerging research trends.

NewsletterTFApr 29

BACTERIAL EDITING TOOLBOX GAINS TRACTION ACROSS SPECIES

Scientists created 'recombitrons' to edit bacterial DNA. This new tool works in 15 different bacteria types, offering a general way to change genes.

#BacterialEditing, #Recombitrons, #GeneEditing, #Microbiology, #ScienceNews

https://newsletter.tf/recombitron-tool-edits-dna-in-15-bacterial-species/

NewsletterTFApr 29

A new DNA editing tool called 'recombitrons' can now change the genes of 15 different types of bacteria, making genetic work easier for scientists.

#BacterialEditing, #Recombitrons, #GeneEditing, #Microbiology, #ScienceNews
https://newsletter.tf/recombitron-tool-edits-dna-in-15-bacterial-species/

New 'Recombitron' Tool Edits DNA in 15 Bacterial Species

Scientists created 'recombitrons' to edit bacterial DNA. This new tool works in 15 different bacteria types, offering a general way to change genes.

NewsletterTF
N-gated Hacker NewsApr 27
🎉 Wow, the #FDA finally figured out what genes are! 🧬 Their #groundbreaking #approval might just cure your hereditary inability to hear reason. 🤦‍♂️ Let's hope they can gene-edit their way to a solution for selective hearing next. 🙉
https://www.fda.gov/news-events/press-announcements/fda-approves-first-ever-gene-therapy-treatment-genetic-hearing-loss-under-national-priority-voucher #GeneEditing #HearingLoss #Innovation #HackerNews #ngated
FDA Approves First-Ever Gene Therapy for Treatment of Genetic Hearing Loss Under National Priority Voucher Program

The U.S. Food and Drug Administration today approved Otarmeni (lunsotogene parvec-cwha), the first-ever dual adeno-associated virus (AAV) vector-based gene therapy.

U.S. Food and Drug Administration
KillBait NewsApr 24

Two US Gene-Editing Startups for Embryos Shut Down Amid Funding and Legal Challenges

📰 Original title: Designer Baby Companies Are in Turmoil

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/two-us-gene-editing-startups-for-embryos-shut-down-amid-funding-and-legal-challenges/?redirpost=55b2b9f0-c7f6-4c97-b9de-1e4f1d39f73b

#genetics #geneediting #embryos #biotechstartups

Two US Gene-Editing Startups for Embryos Shut Down Amid Funding and Legal Challenges

Two American companies, Manhattan Genomics and Bootstrap Bio, both launched with the goal of creating gene-edited babies to prevent serious diseases, have ceased operations.

KillBait Archive
KillBaitApr 24

Two US Gene-Editing Startups for Embryos Shut Down Amid Funding and Legal Challenges

📰 Original title: Designer Baby Companies Are in Turmoil

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/two-us-gene-editing-startups-for-embryos-shut-down-amid-funding-and-legal-challenges/?redirpost=55b2b9f0-c7f6-4c97-b9de-1e4f1d39f73b

#genetics #geneediting #embryos #biotechstartups

Two US Gene-Editing Startups for Embryos Shut Down Amid Funding and Legal Challenges

Two American companies, Manhattan Genomics and Bootstrap Bio, both launched with the goal of creating gene-edited babies to prevent serious diseases, have ceased operations.

KillBait Archive
WIRED - The Latest in Technology, Science, Culture and Business [Unofficial]Apr 24

Designer Baby Companies Are in Turmoil

https://fed.brid.gy/r/https://www.wired.com/story/designer-baby-companies-are-in-turmoil/