Mastodawn

The article discusses a synthetic psychedelic compound, 25C-NBF, that promotes rapid brain cell growth and produces antidepressant-like effects in male rodents with no evident addictive traits. It also examines the compound’s safety profile, neuronal changes, and potential for fast-acting mood improvement.

This topic is of interest to psychology enthusiasts because it highlights how rapid neuroplastic changes can influence mood regulation and behavior, offering insight into mechanisms of depression and the quest for fast-acting treatments.

Article Title: Novel psychedelic compound 25C-NBF shows rapid antidepressant effects without addictive traits

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/novel-psychedelic-compound-shows-rapid-antidepressant-effects-without-addictive/

#psychedelics #depression #neuroplasticity #5HT2A #psychopharmacology #neuroscience #mentalhealth #anhedonia #dopamine #prefrontalcortex

Psychotherapy Commission ACPE Feb 18

Summary: The article discusses how loneliness alters brain processing of social information and how targeted brain stimulation can shift lonely individuals' subjective evaluation of negative social scenes, revealing a disconnect between brain activity and conscious feelings. It reports on a study using transcranial direct current stimulation on the left dorsolateral prefrontal cortex and examines differences between lonely and non-lonely participants.

Why it matters for psychology: The piece highlights the complex relationship between neural processing and subjective experience in loneliness, illustrating how brain modulation can influence perceived negativity and challenge assumptions about self-awareness in emotion regulation. It also underscores the role of metacognition and lateralized prefrontal functioning in social threat processing.

Article Title: Study finds a disconnect between brain activity and feelings in lonely people

Link to PsyPost Article: ift dot tt/3M60n2k

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#loneliness #neuroscience #emotionregulation #prefrontalcortex #psychologyresearch

PLOS Biology Oct 23, 2025

Excitatory input from #PrefrontalCortex to #hippocampus pyramidal cells is believed to be mediated through the thalamic nucleus reuniens. @mick &co show in rodents that this brain pathway is unexpectedly minor, contrary to assumptions in the field
@PLOSBiology plos.io/48u6mle

PLOS Biology Oct 1, 2025

What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @PLOSBiology https://plos.io/4mI4lVO

RationizedInsanity🏳️‍🌈🇺🇦🇨🇦🇬🇱🇵🇸Sep 30, 2025

Something I always wondered about people with #tourettes and #ticdisorders:

We're almost always empaths.

The part of our brain - the #prefrontalcortex - responsible for #empathy is slightly larger than usual while the part of our brain in our #basalganglia regulating motor planning/control, has faulty neuro-pathways and shrunken parts.

More connections to the PFC as an adaptation, resulting in glitchy motor controls but perhaps very deep emotions.

#writing #mentalhealth #neuroscience

PLOS Biology Aug 8, 2025

Lateral #PrefrontalCortex is involved in executive functions, but what roles do distinct anatomical subregions play? This study shows that caudal VLPF specializes in visual input processing, while middle areas support context-based behavioral planning @PLOSBiology https://plos.io/4ljEz9W

PLOS Biology Jul 3, 2025

What role do cortical regions play in #mathematical learning? This study reveals the causal role of dorsolateral #PrefrontalCortex & #frontoparietal network in #math learning using #transcranial neuromodulation in human participants @PLOSBiology https://plos.io/45SyMUI