My review has been published in Frontiers in Physiology.
It discusses evidence linking perinatal asphyxia with schizophrenia spectrum disorders, focusing on how alterations in the indirect pathway may contribute to thalamic disinhibition and the emergence of positive symptoms
https://doi.org/10.3389/fphys.2026.1759386
#Neuroscience #Neurodevelopment #BasalGanglia #Schizophrenia #PerinatalAsphyxia
Frontiers | The indirect pathway hypothesis of schizophrenia: insights from perinatal asphyxia

The comorbidity between perinatal asphyxia (PA) and schizophrenia spectrum disorders (SSD) has been consistently documented in both clinical and experimental...

Frontiers

🧠 New preprint by Greenstreet, Geerts, Gallego, and Clopath on #MotorLearning across #cortex, #cerebellum, and #BasalGanglia.

Key idea: supervised learning builds a low-dimensional action embedding, and #ReinforcementLearning operates directly in this structured space. This explains generalization, interference, and striatal similarity patterns as geometric consequences, not add-ons.

🌍 https://doi.org/10.64898/2025.12.19.695526

#Neuroscience #CompNeuro #RL

Songbird connectomics, from my colleague Joergen Kornfeld:
https://www.songbird-connectomics.org/

Includes the first connectome of basal ganglia.

Three key papers:

"The songbird basal ganglia connectome", Rother et al. 2025 (Kornfeld lab)
https://www.biorxiv.org/content/10.1101/2025.10.25.684569v1

"An anatomical substrate of credit assignment in reinforcement learning", Kornfeld et al. 2025 (with Michael Fee as senior author)
https://www.biorxiv.org/content/10.1101/2020.02.18.954354v2

"Songbird connectome reveals tunnelling of migratory neurons in the adult striatum", Shvedov et al. 2025 (B.B. Scott's lab)
https://www.biorxiv.org/content/10.1101/2025.10.24.684388v1

#neuroscience #connectomics #ZebraFinch #songbirds #BasalGanglia

songbird basal ganglia connectome

songbird basal ganglia connectome
the first songbird #basalganglia #brain connectome:
-8,500 automated neuron reconstructions
-20 million synapses
-16 cell types
https://www.songbird-connectomics.org/

Something I always wondered about people with #tourettes and #ticdisorders:

We're almost always empaths.

The part of our brain - the #prefrontalcortex - responsible for #empathy is slightly larger than usual while the part of our brain in our #basalganglia regulating motor planning/control, has faulty neuro-pathways and shrunken parts.

More connections to the PFC as an adaptation, resulting in glitchy motor controls but perhaps very deep emotions.

#writing #mentalhealth #neuroscience

Before you continue to YouTube

Before you continue to YouTube

Before you continue to YouTube

#BasalGanglia are critical for decision-making, but how are their subregions coordinated? @nadjagingjehli &co show how the different subregions regulate #decision dynamics under varying degrees of conflict & uncertainty in a perceptual decision task #plosbiology https://plos.io/3WC13cq