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Brain circuits tied to depression’s “negativity effect” uncovered

Depression makes the brain more sensitive to negative experiences and less responsive to positive ones, linked to specific brain circuits in the amygdala.

PsyPost
https://www.nature.com/articles/s41467-023-37463-3 Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology (Tian, et al, 2023) #ketamine #brains #psychedelic #psychedelics #brainwaves #neuroscience #braincircuits #psychedelic #psychedelics #psychedelicresearch
Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology - Nature Communications

The neural mechanisms underpinning ketamine’s dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent patterns that may relate to its dissociative and antidepressant effects.

Nature

@LearnTribe
Apparently the #SanFrancisco subject was relieved of their "#chronicDepression" (no mention in the report as to why the person has it in the first place) by having "short #correctiveElectricPulses to reset #brainCircuits associated with #negativeFeelings".

So deeply, deeply concerning.

This is reported like its a #scientificBreakthrough in 2021.

#PR #pressRelations #bigPharma

Bluesky

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