Mastodawn

Study reveals how $RNA travels between cells to control #genes across #generations

#dsRNA #SID-1 #sdg-1 #jumpinggenes #epigenetic #C_elegans

https://phys.org/news/2025-02-reveals-rna-cells-genes-generations.html

Study reveals how RNA travels between cells to control genes across generations

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health care providers can now successfully develop drugs that use dsRNA to accurately target and silence disease-causing genes, a major challenge remains: getting these potentially life-saving RNA molecules into cells efficiently.

Phys.org

CellBioNews Apr 5, 2024

#Insect #immune insights: Researchers unveil immune system dynamics.

#infection #signalling #Toll_pathway #dsRNA #fitness

https://phys.org/news/2024-04-insect-immune-insights-unveil-dynamics.html

Insect immune insights: Researchers unveil immune system dynamics

A paper published in PLoS Pathogens, titled "Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling," delves into the microscopic realm and unravels the orchestrated defense mechanisms led by the molecular regulator cactus.

Zoomers of the Sunshine Coast 🇨🇦Mar 2, 2024

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

We show evidence that viral peptide fragments from SARS-CoV-2 but not harmless coronavirus homologs can “reassemble” with dsRNA into a form of proinflammatory nanocrystalline condensed matter, resulting in cooperative, multivalent immune recognition and grossly amplified inflammatory responses.

#longterm #dsRNA #proinflammatory

https://www.pnas.org/doi/10.1073/pnas.2300644120

CellBioNews Dec 16, 2023

#Myrtle_rust is devastating Australian forests: New high-tech spray holds out hope for native #trees.

#RNA_interference #fungus #Lenwebbia #appressoria #dsRNA

https://theconversation.com/myrtle-rust-is-devastating-australian-forests-a-new-high-tech-spray-holds-out-hope-for-native-trees-219411

Myrtle rust is devastating Australian forests. A new high-tech spray holds out hope for native trees

Australian scientists have developed a cure for myrtle rust which could stop an unprecedented extinction event unfolding in native forests.

The Conversation

CellBioNews Feb 24, 2023

#Deer protected from deadly #disease by newly discovered #genetic differences

#EHD #epizootic #TLR3 #dsRNA #virus #mutation #evolution

https://phys.org/news/2023-02-deer-deadly-disease-newly-genetic.html

Deer protected from deadly disease by newly discovered genetic differences

It was the height of summer 2022 when the calls started coming in. Scores of dead deer suddenly littered rural properties and park preserves, alarming the public and inconveniencing landowners. According to officials at the Urbana Park District, it was Epizootic Hemorrhagic Disease (EHD), a midge-borne viral illness that pops up in white-tailed deer populations around the state every few years. And when susceptible deer are infected, they die within days.

Phys.org

Vivek Mutalik Jan 17, 2023

First-in-human application of double-stranded RNA #bacteriophage in the treatment of pulmonary #Pseudomonas aeruginosa infection -

#dsrna #phagetherapy

https://pubmed.ncbi.nlm.nih.gov/36636832/?utm_source=dlvr.it&utm_medium=twitter&utm_campaign=None&utm_content=12kswG5SFWVCwfirm5JCj21pS7ZfPHNIJmxYoRW1tSSTM88MJ2&fc=None&ff=20230113110624&v=2.17.9.post6%2086293ac

First-in-human application of double-stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection - PubMed

A double-stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin-producing Pseudomonas aeruginosa strain, which was isolated from a 40-year-old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three-course nebuli …

PubMed

Eric Pyrrhus Dec 22, 2022

Replicating #chikungunya #virus, which occurs inside a 'spherule', apparently spends 80% of its time in the double-stranded #RNA intermediate state.

From the preprint:

"A first characterization of the filamentous material in the spherule indicated that each spherule contains a single copy of the viral genome, ~80% of which is present in #dsRNA form."
https://www.biorxiv.org/content/10.1101/2022.12.19.521029v1

Seth Thomas Scanlon Dec 20, 2022

Science Magazine (@sciencemagazine) First Release: Jean-Laurent Casanova & colleagues report that single-gene recessive inborn errors of OAS–RNase L pathway cause #myeloid cells to produce excess #inflammatory #cytokines following #dsRNA or #SARSCoV2 stimulation. This pathway may drive #MISC, a rare complication of #COVID19 in some #children!

https://bit.ly/Sci_abo3627