2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.
CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.
#OpenAccess #virology #immunology #microbiology #phage #bacteriophage
https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html
Not just passengers: Phages as agents of genetic exchange in fecal #microbiota transplantation.
#Phage ‑mediated gene transfer may shape FMT outcomes by altering gut communities and microbial functions.
#bacteriophage #microbiology #virology #virome
https://davidojcius.blogspot.com/2026/04/not-just-passengers-phages-as-agents-of.html
Phage P100 resistance in clinical & foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations & fitness trade-offs.
Study shows diverse P100 resistance mechanisms in #Listeria & significant serovar‑dependent fitness costs.
https://davidojcius.blogspot.com/2026/02/phage-p100-resistance-in-clinical-and.html #OpenAccess #bacteriophage #phage #food
Bacteriophage cocktail in drinking water suppresses systemic avian pathogenic Escherichia coli infection and pathology in laying hens.
High‑MOI phages cut APEC morbidity and mortality by 20–30%. Oral delivery worked best, removed lesions, lowered histology scores, and the cocktail stayed active without harming the cecal microbiota.
https://davidojcius.blogspot.com/2026/02/bacteriophage-cocktail-in-drinking.html #OpenAccess #microbiology #bacteriophage #phages #chickens
#Bacteriophage cocktail in drinking water suppresses systemic avian pathogenic Escherichia coli infection and pathology in laying hens
https://www.sciencedirect.com/science/article/pii/S2666517426000246 #OpenAccess #Ecoli #phages #microbiology
Molecular basis for anti-jumbo phage #immunity by AVAST type 5.
Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.
https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology
🧬 Golden Gate method enables fully-synthetic engineering of therapeutically relevant bacteriophages
https://phys.org/news/2026-01-golden-gate-method-enables-fully.html
#molbio #virus #bacteriophage #bacteria #microbes #biotech #gmo
Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century. As antibiotic-resistant infections increasingly threaten public health, interest in bacteriophages as therapeutics has seen a resurgence. However, the field remains largely limited to naturally occurring strains, as laborious strain engineering techniques have limited the pace of discovery and the creation of tailored therapeutic strains.
David Ojcius
PLOS Biology
Paul Houle
Hacker News
