Mastodawn

Mucin modulates phage infection dynamics and #biofilm formation in enteropathogenic #Yersinia enterocolitica

#OpenAccess #biofilms #microbiology #bacteriophage #phages

https://davidojcius.blogspot.com/2026/06/mucin-modulates-phage-infection.html

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

Bacteriophages: meet the viruses that hunt superbugs | The-14

Bacteriophages are viruses that target harmful bacteria, offering a promising alternative to antibiotics and helping fight rising antimicrobial resistance worldwide.

The-14 Pictures

David Ojcius Apr 19

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

David Ojcius Apr 16

Not just passengers: Phages as agents of genetic exchange in fecal #microbiota transplantation.

#Phage ‑mediated gene transfer may shape FMT outcomes by altering gut communities and microbial functions.

#bacteriophage #microbiology #virology #virome

https://davidojcius.blogspot.com/2026/04/not-just-passengers-phages-as-agents-of.html

PLOS Biology Apr 1

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

David Ojcius Feb 27

Phage P100 resistance in clinical & foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations & fitness trade-offs.

Study shows diverse P100 resistance mechanisms in #Listeria & significant serovar‑dependent fitness costs.

https://davidojcius.blogspot.com/2026/02/phage-p100-resistance-in-clinical-and.html #OpenAccess #bacteriophage #phage #food

David Ojcius Feb 16

Bacteriophage cocktail in drinking water suppresses systemic avian pathogenic Escherichia coli infection and pathology in laying hens.

High‑MOI phages cut APEC morbidity and mortality by 20–30%. Oral delivery worked best, removed lesions, lowered histology scores, and the cocktail stayed active without harming the cecal microbiota.

https://davidojcius.blogspot.com/2026/02/bacteriophage-cocktail-in-drinking.html #OpenAccess #microbiology #bacteriophage #phages #chickens

David Ojcius Feb 16

#Bacteriophage cocktail in drinking water suppresses systemic avian pathogenic Escherichia coli infection and pathology in laying hens

https://www.sciencedirect.com/science/article/pii/S2666517426000246 #OpenAccess #Ecoli #phages #microbiology

David Ojcius Feb 7

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

Paul Houle Feb 1

🧬 Golden Gate method enables fully-synthetic engineering of therapeutically relevant bacteriophages

https://phys.org/news/2026-01-golden-gate-method-enables-fully.html

#molbio #virus #bacteriophage #bacteria #microbes #biotech #gmo

Golden Gate method enables fully-synthetic engineering of therapeutically relevant bacteriophages

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century. As antibiotic-resistant infections increasingly threaten public health, interest in bacteriophages as therapeutics has seen a resurgence. However, the field remains largely limited to naturally occurring strains, as laborious strain engineering techniques have limited the pace of discovery and the creation of tailored therapeutic strains.

Phys.org