Amelia Cervera 🧬Modulation of protein activity by small RNA base pairing internal to coding sequences.
#RNA #smallRNAs #Translation #Ecoli
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00258-8
A tripartite cell-free translation system to study mammalian translation.
#RNA #Translation #Cell-FreeSystem #Mammals #Protocols
A tripartite cell-free translation system to study mammalian translation - Nature Protocols
This protocol presents a tripartite mammalian cell-free translation system, comprising cytoplasmic and ribosome fractions combined with endogenous or synthetic mRNAs, permitting flexible reconstitution and careful dissection of the mechanisms of translation.
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.
#RNA #Transcription #NuclearExport #NuclearSpeckles #TranscriptionInhibition #CancerTherapy
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)01004-9
LaborjournalDie #Trump-Regierung überzieht die US-#Wissenschaft mit Attacken, Repressalien und Chaos. Wie sich das konkret auf Forschende auswirkt, darüber sprach Bettina Dupont für uns mit Andrea Schorn, deutsche #RNA-Forscherin am Cold Spring Harbor Laboratory: https://www.laborjournal.de/rubric/hintergrund/hg/hg_25_04_03.php
Hintergrund - Deutsche Forscherin in den USA: Das Land setzt seine Spitzenstellung aufs Spiel
US-Präsident Donald Trump versetzt die Wissenschaft der USA mit Kündigungen, Entlassungen und Budgetkürzungen ins Chaos. Wir sprachen darüber mit der deutschen RNA-Forscherin Andrea Schorn am Cold Spring Harbor Laboratory CSHL.
Paul Houle🛡️ RNA interference and nanomedicine join forces to fight dangerous fungal infections
https://phys.org/news/2025-03-rna-nanomedicine-dangerous-fungal-infections.html
RNA interference and nanomedicine join forces to fight dangerous fungal infections
Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group, in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 million died as a result—nearly twice as many as in 2012. Even with medications, known as antifungals, the mortality rate for invasive infections caused by the mold Aspergillus fumigatus is as high as 85%. As resistant fungal strains increase, treatment becomes more difficult, and new therapies are urgently needed.
Tino EberlEin neuer #Bluttest könnte #Parkinson bereits erkennen, bevor erste Symptome auftreten.
Forschende analysieren dabei einfach, schnell und kostengünstig spezifische #RNA-Fragmente im Blut. Der Test zeigte eine hohe #Genauigkeit und könnte die #Früherkennung sowie gezielte Therapien deutlich verbessern.
#Neurologie #Früherkennung #Biomarker #Medizin #Diagnostik #ParkinsonForschung #Gesundheit
nf-corePipeline release! nf-core/hlatyping v2.1.0 - 2.1.0 - Chewbacca!
Please see the changelog: https://github.com/nf-core/hlatyping/releases/tag/2.1.0
#dna #hla #hlatyping #immunology #optitype #personalizedmedicine #rna #nfcore #openscience #nextflow #bioinformatics
JIPB#RNA interference is an important tool to protect #plants from #pathogens and pests, but delivery can be problematic. In this #JIPB review, Xing et al. explore the potential of engineered #nanotransporters for RNAi delivery.
https://doi.org/10.1111/jipb.13887
@wileyplantsci
#PlantSci #RNAi #Nanotech #botany
https://doi.org/10.1111/jipb.13887
@wileyplantsci
#PlantSci #RNAi #Nanotech #botany
Keiran RowellThe latest #InThePipeLine by #chemistry commentator Derek Lowe discusses some amazing #RNA 3D structures and the 'alien world' it provides a peek into.
https://www.science.org/content/blog-post/rna-motifs-coming-focus
"Minor-groove interactions, KL interactions, TL/TLR interactions, three-way and four-way junctions, A-stacking. . .these sorts of things had already been observed in the ways that single strands of RNA fold up on themselves, and they're part of these multimeric structures, too."
preLightsAn intriguing twist! TDP-43 (linked to #ALS) keeps RNAs out of neuronal projections by making them unstable, preventing RNA buildup in neurites. #preprint from the #TaliaferroLab
Another excellent post prepared by Felipe Del Valle Batalla 🙌
#preLight ⬇️ 👀
https://prelights.biologists.com/highlights/tdp-43-directly-inhibits-rna-accumulation-in-neurites-through-modulation-of-rna-stability/
