Mastodawn

PLOS Biology Apr 24, 2024

When considering #PhageTherapy, are there any direct effects of #phage on the human host? @jbombscientist &co show that therapeutic phages can be detected by human #RespiratoryTract epithelial cells & can elicit #proinflammatory responses. #PLOSBiology https://plos.io/44dOUgu

Lytic bacteriophages induce the secretion of antiviral and proinflammatory cytokines from human respiratory epithelial cells

Phage therapy is being explored to treat multidrug-resistant bacterial infections, but the possible direct effects of phages on the human host are less well understood. This study shows that therapeutic phages can be detected by epithelial cells of the human respiratory tract, eliciting proinflammatory responses that depend on specific phage properties and the airway microenvironment.

PLOS Biology Mar 7, 2024

#Autophagy maintains cellular homeostasis by selectively degrading cytoplasmic cargoes; defects in this pathway can lead to #proinflammatory disease. This study shows that selective degradation of the #immunoproteasome regulates innate inflammatory signaling #PLOSBiology https://plos.io/49FpyKB

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits

Autophagy maintains cellular homeostasis by the selective degradation of cytoplasmic cargoes, and defects in this pathway can lead to several proinflammatory diseases. This study shows that selective degradation of the immunoproteasome regulates innate inflammatory signalling.

Zoomers of the Sunshine Coast 🇨🇦Mar 2, 2024

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

We show evidence that viral peptide fragments from SARS-CoV-2 but not harmless coronavirus homologs can “reassemble” with dsRNA into a form of proinflammatory nanocrystalline condensed matter, resulting in cooperative, multivalent immune recognition and grossly amplified inflammatory responses.

#longterm #dsRNA #proinflammatory

https://www.pnas.org/doi/10.1073/pnas.2300644120

Scientific Frontline Feb 25, 2024

#Australian researchers have found that a family of #proinflammatory #molecules called beta common #cytokines control inflammation and scarring of the airways (fibrosis) in severe and steroid-resistant #asthma.
#Medical #sflorg
https://www.sflorg.com/2024/02/med02252402.html

Targeting inflammatory protein could help treat severe asthma

Inflammation and tissue damage in severe asthma is caused by several types of immune cells

The EMBO Journal Feb 12, 2024

Apoptotic #mitochondrial outer membrane permeabilization MOMP is #proinflammatory because of mitochondrial membrane protein ubiquitylation leading to NEMO recruitment and NF-kB activation

Stephen Tait and colleagues

https://www.embopress.org/doi/full/10.1038/s44318-024-00044-1