Mastodawn

There’s a #new #antibiotic out there: #Lariocidin doesn't seeeeeem to be toxic to human cells, making it a super #promising candidate for new #medicines. This discovery is a GINORMOUSSS leap of hope in our battle against #superbugs. https://www.linkedin.com/posts/lucylawrence_i-know-i-say-alot-of-things-are-huge-activity-7325455540250189825-F4Je?utm_source=share&utm_medium=member_ios&rcm=ACoAAACBLh8BKizVOxJMKKqeH-rrEMhwmUcweK4

🙀 I know I say alot of things are huge, but seriously, this is… | Lucy Lawrence

🙀 I know I say alot of things are huge, but seriously, this is MASSIVE!🙀 Scientists have found a brand-new antibiotic, called lariocidin, and it's naturally made by bacteria. The thing that makes it so exciting is that it attacks bacteria in a completely different way than the antibiotics we use now. And this is a game changer because antibiotic resistance is a 🦠 HUGE🦠 problem, it takes the lives of over 1 million people globally (my close family members included) Our old drugs are basically losing their power, and so many scientists are desperately searching for need new ones. But it's been almost 30 YEARS since a totally new type of antibiotic hit the market! 🤯 So the thing that makes lariocidin different is its shape. It's like a lasso knot – super strong and stable. And this is what means it can attach to a crucial part of the bacteria (the ribosome, its protein-making factory) in a way that other antibiotics just can't. And even better is that its been shown to work against bacteria that are resistant to other drugs, including MRSA!!!🦠 ANDDD, Lariocidin doesn't seeeeeem to be toxic to human cells, making it a super promising candidate for new medicines. Of course, there's still a long road ahead before this hits pharmacies, but this discovery is a ✨ GINORMOUSSS ✨ leap of hope in our battle against superbugs 🦠 🔎 https://lnkd.in/emcUn7uq

Nick Byrd, Ph.D.May 3

#Japan launched a national plan to reduce #AntimicrobialResistance in 2016.

Data from 2012 to 2020 show a pretty clear, abrupt, and consistent reduction in overall and inappropriate #antibiotic #prescription corresponding to the launch.

https://doi.org/10.1093/jacamr/dlaf062

#medicine #xRisk

Chemistry Research Apr 29

Researchers from #Germany have isolated a novel #antibiotic named saarvienin A. The glycopeptide was obtained from an Amycolatopsis strain by Rolf Müller and his team and was described in the journal Angewandte Chemie. With a completely novel structure, it exhibits excellent antibiotic activity against Gram-positive bacteria and can overcome vancomycin resistance. However, cytotoxicity against eukaryotic cells has also been observed.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202425588

#chemistry #medchem #science

Nick Byrd, Ph.D.Apr 17

Apparently the #antimicrobialResistance community found #Buzzfeed.

Nearly 25% of this list about "#Health 'Lies'" is #AMR ranting. 🤣

6. "an #antibiotic and WILL NOT cure your cold. Colds are viruses. ...a mild cough, congestion, and sore throat DOES NOT require a doctor...."

PLOS Biology Apr 9

PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. This study uses PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @PLOSBiology https://plos.io/3G2myhf

Extreme diversity of phage amplification rates and phage–antibiotic interactions revealed by PHORCE

PHORCE is a new high-throughput method that enables precise measurement of lytic phage amplification rates in bacterial populations. Using PHORCE, this study reveals broad phenotypic diversity among E. coli and P. aeruginosa phages and shows that phage-antibiotic interactions are primarily determined by the antibiotic.

Kylee Apr 8

This is so cool! Literally the project my students are doing in #microbiology this quarter, and it yielded a new CLASS of #antibiotic, which the world badly needs. #science #GoodNews https://healthsci.mcmaster.ca/a-breakthrough-moment-mcmaster-researchers-discover-new-class-of-antibiotics/

naturaldynamics Apr 7

The last time a new class of antibiotics reached the market was nearly three decades ago—but that could soon change, thanks to a discovery by researchers at McMaster University.
https://phys.org/news/2025-03-breakthrough-moment-class-antibiotics.html?ref=fixthenews.com
#canada. #antibiotic, #healthcare

A breakthrough moment: Researchers discover new class of antibiotics

The last time a new class of antibiotics reached the market was nearly three decades ago—but that could soon change, thanks to a discovery by researchers at McMaster University.

Phys.org

michael Apr 3

2-Apr-2025
New #antibiotic for multidrug resistant #superbug
Researchers from the universities in Konstanz and Vienna discover a new class of antibiotic that selectively targets Neisseria gonorrhoeae, the bacterium that causes #gonorrhoea.

https://www.eurekalert.org/news-releases/1079168 #science #medicine #AntibioticsResistance

New antibiotic for multidrug resistant superbug

Researchers from the universities in Konstanz and Vienna discover a new class of antibiotic that selectively targets Neisseria gonorrhoeae, the bacterium that causes gonorrhoea. These substances trigger a self-destruction program, which also operates in multi-resistant variants of the pathogen. The novel findings are published in the current issue of Nature Microbiology.

EurekAlert!

Daniel Hoffmann 🥬Apr 3

Antibiotics cause damage of gut microbiome of human babies, which in turn reduces #vaccine efficacy. In the mouse model, vaccine efficacy after #antibiotic treatment can be restored with #probiotics. https://www.nature.com/articles/s41586-025-08796-4

Bifidobacteria support optimal infant vaccine responses - Nature

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probiotic therapy could be beneficial.

Nature