PLOS BiologyApr 9, 2025
PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. This study uses PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @PLOSBiology https://plos.io/3G2myhf
Extreme diversity of phage amplification rates and phage–antibiotic interactions revealed by PHORCE

PHORCE is a new high-throughput method that enables precise measurement of lytic phage amplification rates in bacterial populations. Using PHORCE, this study reveals broad phenotypic diversity among E. coli and P. aeruginosa phages and shows that phage-antibiotic interactions are primarily determined by the antibiotic.

PLOS BiologyFeb 14, 2024
How do #bacteria detect other species? @kdyarrington @tnshendruk @DominiqueLimoli show that when traveling on surfaces by type IV pili-mediated motility, #Paeruginosa uses the #chemoreceptor PilJ to detect & respond to interspecies signals #PLOSBiology https://plos.io/3I1XTat
The type IV pilus chemoreceptor PilJ controls chemotaxis of one bacterial species towards another

Bacteria live in social communities, where the ability to sense and respond to interspecies and environmental signals is critical for survival. This study shows that when traveling on surfaces by type IV pili mediated motility, the bacterium Pseudomonas aeruginosa uses a designated chemoreceptor, PilJ, to detect and respond to interspecies signals.

Show threadProfessor Lesley HoylesFeb 22, 2023

- first pBT2436-like megaplasmid reported in Egypt
- first genomic data for #Paeruginosa associated with #CAUTI in Egypt
- AMR genotypic and phenotypic #discordance is a real issue with P. aeruginosa

There's a lot more great work to come from Mohamed's study. Looking forward to seeing it out in the next 12 months.

*proud supervisor* :)