Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I take photos, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

The 5th Virtual #ChemBioTalks continue with an insightful talk by Kelly Chibale. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. https://onlinelibrary.wiley.com/doi/10.1002/anie.202425206

Very much looking forward to the talk by Kelly Chibale at the 5th Virtual @ChemBioTalks and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria.

#ChemBio #Chemistry #DrugDiscovery

Very much looking forward to the talk by @kellychibale.bsky.social at the 5th Virtual @chembiotalks.bsky.social and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria. #ChemBio #ChemSky #DrugDiscovery

RE: https://bsky.app/profile/did:plc:ucyautp3h3p3klrxkh4tsyc7/post/3lvkmqwtdjf2v
3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
https://www.nwo.nl/en/news/49-take-off-projects-awarded-in-spring-round-2025
49 Take-off projects awarded in spring round 2025 | NWO

38 feasibility studies and 11 vroegefasetrajecten have been awarded in the 2025 spring round of Take-off. The Take-off program gives researchers in phase 1 the opportunity to test the feasibility of commercializing their idea based on innovative research results. In phase 2, knowledge-based, innovative start-ups in the early stages of their development receive a loan to get their business off the ground.

NWO

SciTech Chronicles . . . .May 8th, 2025

https://bit.ly/stc050825

#SIK3 #NSS #profile #kinase #pathogens #intercontinental #balloons #"35 kilometers" #"jurema preta" #dimethyltryptamine #"no ban" #"Mimosa tenuiflora" #TYK2 #psoriasis #inhibitor #signaling #Friendship #"Lamprotornis superbus" #reciprocal #DNA

SciTech Chronicles. . . . . . . . .May 8th, 2025

You've got two good eyes and you still can't see. Vol II No 32 455 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy...

SciTech Chronicles. . . . . .May 6th, 2025

https://bit.ly/stc050625

#EphB1/2 #tyrosine #kinase #inhibitors #carbene #thiamine #Breslow #B1 #3D-printable #electroencephalogram #continuously #bioadhesive #AMT #mesothelioma #"low-carbon metal oxides" #CO2 #"digital twin" #"3D digital model" #sonar #Magellan

SciTech Chronicles. . . . . . . . .May 6th, 2025

We are Volunteers of America. Vol II No 30 371 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy Me A Coffee New Mol...

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors. #ABPP #ChemSky #ChemBio
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