🧬 Could a single metric decode how genes are regulated across cells?

πŸ”— Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

πŸ“š CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

Researchers have developed a method to deduce the complete protein landscape (proteome profile) of a living cell without destroying it by utilizing Raman spectroscopy. This light-based technique allows scientists to observe exactly how cells balance internal stability with the flexibility needed to survive changing environments.
#Biophysics #Proteomics #Optics #SystemsBiology #sflorg
https://www.sflorg.com/2026/04/phy04282601.html
Cells under the spotlight reveal their inner secrets

Raman spectroscopy shows researchers how cells can be stable yet adaptable

International Course on #Computational #SystemsBiology of #Cancer taking place at Institut Curie from September 21st – 25th, 2026 (Paris campus).

The course will review current methods and tools for analysing and interpreting multimodal genomic data, with a focus on generative artificial intelligence and network approaches, as well as concrete applications related to cancer.

More details and registration: https://training.institut-curie.org/courses/csbc2026

Welcome to the latest edition of the "What Is" series, presented by the Scientific Frontline publication. In this research report, we delve into one of the most ambitious, technologically demanding, and philosophically profound frontiers in modern biological science: Connectomics.
#WhatIs #Neuroscience #SystemsBiology #ComputationalNeuroscience #ArtificialIntelligence #Bioinformatics #sflorg
https://www.sflorg.com/2026/04/wi04262601.html
What Is: Connectomics

Connectomics operates on the staggering hypothesis that human identity and mental pathology are physically encoded in our unique neural wiring.

βš›οΈ Could life itself be a quantum phenomenon disguised as biology?

πŸ”— Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

πŸ“š CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

πŸ“’ Call for Papers: Metabolome-Microbiome in Health and Diseases for One Health

⏳ Submission Deadline: 31 May 2026

πŸ”— Submit your work: https://spj.science.org/journal/csbj/si/metabolome-microbiome-health-diseases

#CallForPapers #Metabolomics #Microbiome #SystemsBiology #OneHealth #DiseaseBiology #MedicalInformatics #Phenomics

🧬 Can AI truly decode gene expression, or is it being misled by too much data?

πŸ”— Artificial Intelligence in Bulk RNA-Seq: Challenges and Potential Solutions. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0039

πŸ“š CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#ArtificialIntelligence #MachineLearning #Bioinformatics #Genomics #RNAseq #ComputationalBiology #SystemsBiology #AI #PrecisionMedicine #BigData #AIinHealthcare

βš›οΈ Can we design drugs that stabilize biomolecular interactions instead of blocking them?

πŸ”— In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0016

πŸ“š CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign #SystemsBiology #MedicinalChemistry

🀯 What if most β€œbiological insights” are just mixed-up signals we never untangled?

πŸ”— Integrative Learning of Disentangled Representations from Single-Cell RNA-Sequencing Datasets. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0015

πŸ“š CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#SystemsBiology #Genomics #Bioinformatics #ComputationalBiology #AIinBiology #SingleCell #MachineLearning #DataScience #LifeSciences

🧬 Can we map the cascade of gene activity that guides cells through differentiation?

πŸ”— Pseudotimecascade Visualizes Gene Expression Cascade in Pseudotime Analysis. Computational and Structural Biotechnology Journal (CSBJ). https://spj.science.org/doi/epdf/10.34133/csbj.0007

πŸ“š CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#SingleCell #Genomics #Bioinformatics #SystemsBiology #GeneExpression #ComputationalBiology