Our (@kaletalab) new study uncovers multi-level metabolic disruptions in #IBD involving reduced #HostMicrobiomeInteractions.

Elevated tryptophan catabolism → NAD biosynthesis impaired.

Disrupted nitrogen homeostasis affects polyamine/glutathione metabolism.

Suppressed C1 cycle alters NAD/phospholipid profiles.

#MetabolicModeling predicts dietary interventions to restore #Microbiome balance.

Read and share: https://rdcu.be/eo7B3
#SystemsBiology #Microbiome #MultiOmics #CAU #UKSH #Kiel