Jan TaubenheimNew review out: "Metabolic Modeling of Host–Microbe Interactions". In the article, we:
Outline strategies for coupling host and microbial genome scale metabolic models #GEM
Highlight successful applications revealing #HostMicrobiome cross-feeding
Discuss challenges (regulation, dynamics, model validation) and possible solutions
Outline fields which are worthwhile exploring from a #SystemsBiology perspective
We are looking for a #PhD student who applies #MetabolicModeling to explore metabolic #hostMicrobeInteraction in the #gutBrainAxis for #coginitiveDecline during #menopause. A special focus will be laid on the role of the #microbiome in the production/degradation of hormones and the consequences on the brain. Please share and recommend!
More infos here:
https://bsky.app/profile/kaletalab.bsky.social/post/3m2qlozorvs27
Ad for the vacancy is here:
https://www.uniklinikum-jena.de/menobrain/en/Recruitment+_+Open+Calls/DC+8+_+UKSH-p-42.html
Christoph Kaleta (@kaletalab.bsky.social)
1/4 🌍 We are looking for a passionate #PhD student in #Metabolic #Microbiome #Modeling in the Marie Skłodowska-Curie Doctoral Network MenoBrain. Join us at one of Europe’s microbiome research hubs and push the boundaries of microbiome science! @uni-kiel.de 🔗 https://www.uniklinikum-jena.de/menobrain/en/Recruitment+_+Open+Calls/DC+8+_+UKSH-p-42.html
Our (@kaletalab) new study uncovers multi-level metabolic disruptions in #IBD involving reduced #HostMicrobiomeInteractions.
Elevated tryptophan catabolism → NAD biosynthesis impaired.
Disrupted nitrogen homeostasis affects polyamine/glutathione metabolism.
Suppressed C1 cycle alters NAD/phospholipid profiles.
#MetabolicModeling predicts dietary interventions to restore #Microbiome balance.
Read and share: https://rdcu.be/eo7B3
#SystemsBiology #Microbiome #MultiOmics #CAU #UKSH #Kiel