AlphaGenome: AI for better understanding the genome - Google DeepMind
https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome
https://news.ycombinator.com/item?id=44387659

Comment: even in well-studied organisms (E. coli; yeast: Saccharomyces; minimal synthetic cells ...) the function of a staggering number of essential genes is unknown.

#AlphaGenome #DeepMind #MolecularGenetics #Genomics #FunctionalGenomics

🧬 How do AlphaFold2 and ESMFold stack up when it comes to functional annotation?

🔗 AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.01.008

📚 CSBJ: https://www.csbj.org/

#AlphaFold2 #ESMFold #AIinScience #ProteinStructure #Enzymes #Pfam #UniProt #AlphaFold #HumanProteome #FunctionalAnnotation #AIinBiology #ComputationalBiology #FunctionalGenomics

That's a wrap! Sally Temple, Taylor Bertucci and Kate Tubbesing all spoke at the annual #NIHfunded Alzheimer's Disease Sequencing Project #FunctionalGenomics meeting at the @Gladstone Institutes.

#ADSP #FunGen #Alzheimers
#organoid #neurovascular

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers
https://www.science.org/doi/10.1126/sciadv.ado2830
pdf: https://www.science.org/doi/epdf/10.1126/sciadv.ado2830

* diverse regulatory roles in cancer

#cancer #genetics #genomics #FunctionalGenomics #NoncodingDNA #ncDNA #miRNA #GeneRegulation #CRISPR

Why is it so hard to rewrite a genome?
https://www.nature.com/articles/d41586-025-00462-z

Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

#biology #MolecularBiology #SyntheticBiology #GeneticEngineering #genomics #FunctionalGenomics #JCVI

We had a great time this week at the annual meeting of the National Institute on Aging (NIA) sponsored #Alzheimers Disease Sequencing Project (ADSP) #FunctionalGenomics Consortium!

The global ADSP effort seeks to identify and functionally test genetic variants linked to Alzheimer's Disease and AD-related dementias, as well as variants that can be protective against these conditions.

ADSP | https://zurl.co/CtaU
FunGen | https://zurl.co/eivv

Postdoctoral Research Associate in Functional Genomics

Washington University School of Medicine

‘Come join us in @WashUGenetics as a #FunctionalGenomics postdoc’

See the full job description on jobRxiv: https://jobrxiv.org/job/washington-university-school-of-medicine-27778-postdoctoral-research-associate-in-functional-genomics-3/?feed_id=51371

#Sc...
https://jobrxiv.org/job/washington-university-school-of-medicine-27778-postdoctoral-research-associate-in-functional-genomics-3/?feed_id=51371