Mastodawn

Ocular coloboma is a congenital eye defect that occurs when the optic fissure fails to close properly during early development. Recent research utilizing lab-grown, miniature human retinas—known as retinal organoids—has identified how mutations in a specific growth-controlling protein contribute to this condition.
#MolecularGenetics #DevelopmentalBiology #Ophthalmology #sflorg
https://www.sflorg.com/2026/04/gen04132601.html

Lab-grown retina gives gene change clue to rare childhood eye condition

Coloboma arises when a structure in the developing eye, the optic fissure, fails to close properly and often co‑occurs with other tissue‑fusion proble

Scientific Frontline Apr 6

This novel therapeutic approach utilizes specialized lipid nanoparticles (LNPs) to deliver follistatin messenger RNA (mRNA) directly to lung tumors, simultaneously inhibiting cancer growth and reversing cachexia, a severe muscle-wasting syndrome.
#Oncology #Pharmacology #Nanomedicine #MolecularGenetics #cancer #sflorg
https://www.sflorg.com/2026/04/ongy04062601.html

Researchers find way to treat lung cancer and associated muscle wasting at the same time

Lung cancer is the leading cause of cancer death in the United States, and cachexia is responsible for up to 30% of those fatalities

Scientific Frontline Apr 1

A chemical compound, an analog of G2, that prevents neuronal death by enhancing autophagy to clear harmful, misfolded tau proteins from brain cells.
#Neuroscience #CellBiology #Neuropharmacology #MolecularGenetics #sflorg
https://www.sflorg.com/2026/04/ns04012601.html

Chemical compound clears cellular waste, protects neurons in model of frontotemporal dementia

Restoring autophagy is promising strategy for range of neurodegenerative diseases

Victoria Stuart 🇨🇦 🏳️‍⚧️Jul 3, 2025

Global genetic interaction map of human cell reveals conserved principles of genetic networks
https://www.biorxiv.org/content/10.1101/2025.06.30.662193v1?rss=1

#interactome #MolecularGenetics #genetics #FunctionalGenetics

Victoria Stuart 🇨🇦 🏳️‍⚧️Jun 27, 2025

The Talented Dr. Snyder. Massive biomolecular shifts occur in our 40s/60s
https://med.stanford.edu/news/all-news/2024/08/massive-biomolecular-shifts-occur-in-our-40s-and-60s--stanford-m.html

Nonlinear dynamics of multi-omics profiles in human aging
https://www.nature.com/articles/s43587-024-00692-2
https://news.ycombinator.com/item?id=44393547

#MolecularGenetics #aging #StanfordU #MikeSnyder #CellBiology

Massive biomolecular shifts occur in our 40s and 60s, Stanford Medicine researchers find

Time marches on predictably, but biological aging is anything but constant, according to a new Stanford Medicine study.

News Center

Victoria Stuart 🇨🇦 🏳️‍⚧️Jun 27, 2025

AlphaGenome: AI for better understanding the genome - Google DeepMind
https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome
https://news.ycombinator.com/item?id=44387659

Comment: even in well-studied organisms (E. coli; yeast: Saccharomyces; minimal synthetic cells ...) the function of a staggering number of essential genes is unknown.

#AlphaGenome #DeepMind #MolecularGenetics #Genomics #FunctionalGenomics

AlphaGenome: AI for better understanding the genome

Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

Google DeepMind

Victoria Stuart 🇨🇦 🏳️‍⚧️Apr 2, 2025

[biological evolution] Whole-genome duplication drives long-term adaptation
https://www.sciencedaily.com/releases/2025/03/250326221649.htm
https://news.ycombinator.com/item?id=43515443

Genome duplication in a long-term multicellularity evolution experiment
https://www.nature.com/articles/s41586-025-08689-6

#yeast #MolecularBiology #evolution #genetics #MolecularGenetics #multicellularity #adaptation #genomics #GenomeDuplication #CellBiology

Scientists uncover key mechanism in evolution: Whole-genome duplication drives long-term adaptation

Scientists uncovered how whole-genome duplication emerges and remains stable over thousands of generations of evolution in the lab.

ScienceDaily

Victoria Stuart 🇨🇦 🏳️‍⚧️Mar 21, 2025

Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
https://www.sciencedaily.com/releases/2025/03/250320144758.htm
https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer

* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material

Structural dynamics of DNA unwinding by a replicative helicase
https://www.nature.com/articles/s41586-025-08766-w#Sec25

#cancer #MolecularGenetics #StructuralBiology #DNAreplication #DNAhelicase

Breakthrough molecular movie reveals DNA's unzipping mechanism with implications for viral and cancer treatments

Scientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material.

ScienceDaily

Victoria Stuart 🇨🇦 🏳️‍⚧️Feb 4, 2025

Mitochondria as you’ve never seen them
https://www.nature.com/immersive/d41586-025-00269-y/index.html
https://news.ycombinator.com/item?id=42899168

Comments
me: former mitochondrial (mt) researcher, published
mt difficult to prepare/isolate intact/pure
extraordinary imagery shows why

Yet another "illustration" 😉 of crit imp. of fundamental research

https://www.niehs.nih.gov/research/atniehs/labs/gisbl/pi/mdnar
https://tools.niehs.nih.gov/polg/ --> mt. diseases ...
https://en.wikipedia.org/wiki/Mitochondrial_disease

#BasicScience #mitochondria #CellBiology #PolG #disease #BasicResearch #MolecularGenetics #PEO #mtDNA #NIEHS