PLOS BiologyOct 23
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @PLOSBiology plos.io/3Wft0Xg
PLOS BiologyJun 24, 2024
#Candida biofilm formation. @laxmirai @c_denfert &co identify novel modulators of #Calbicans #biofilm formation, revealing that the TFs ZCF15 & ZCF26 regulate metabolic reprogramming during the transition from planktonic to biofilm growth #PLOSBiology https://plos.io/3VVGYOs
Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26

Fungal biofilms are complex communities that can form on surfaces of implanted medical devices. This study uses an overexpression screen to identify novel modulators of Candida albicans biofilm formation, revealing that the transcription factors ZCF15 and ZCF26 regulate metabolic reprogramming during the transition from planktonic to biofilm growth.