CSBJSep 30, 2025

🧠 Could reprogramming RNA offer a new path to brain aneurysm therapies?

🔗 In-depth analysis of the RNA editing landscape in intracranial aneurysms and its potential role in alternative splicing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.021

📚 CSBJ: https://www.csbj.org/

#RNAediting #IntracranialAneurysm #Neuroscience #Genomics #PrecisionMedicine #MedicalResearch #BrainHealth #StrokeResearch

Did You KnowAug 31, 2025
Octopuses can edit their own RNA, allowing them to rapidly adapt to environmental changes without waiting for genetic mutations. Nature's ultimate biohackers! 🌍🔬 #OctopusMagic #RNAEditing #Adaptation #Evolution #NatureInnovation #ScienceFacts
Cytology and GeneticsAug 14, 2025
The Complete Mitochondrial Genomes of Two Apple Cultivars Reveal the Highly Conserved Structure in Cultivated Apples - #cultivatedapple #mitochondrialgenome #mitochondrialplastidsequence #RNAeditingsites #phylogeneticanalysis #apple #mitochondria #sequence #RNAediting #CompleteMitochondrialGenomes - https://link.springer.com/article/10.3103/S0095452725020057
The Complete Mitochondrial Genomes of Two Apple Cultivars Reveal the Highly Conserved Structure in Cultivated Apples - Cytology and Genetics

Abstract Apples are one of the most popular and economically important fruits worldwide and have both nutritional and ornamental value. However, because of their complexity, studies on apple mitochondrial (mt) genomes have been limited. In this study, the mt genomes of Aksu Fuji and Ralls Janet cultivars were assembled, annotated, and analyzed based on a hybrid strategy using Illumina, and comprehensive comparisons of their structure, gene content, intercellular gene transfer, phylogeny, and RNA editing sites were performed. The mt genome length and gene structure of the two apple cultivars were identical (396 592 bp) and included 63 protein-coding genes (PCGs), 20 transfer RNA (tRNA) genes, and 4 ribosomal RNA (rRNA) genes. There were 44 and 31 mitochondrial plastid fragments (MTPTs) identified between the mt and plastid genomes of the Ralls Janet and Aksu Fuji cultivars, accounting for 1.98 and 2.19% of their mt genomes, respectively. Furthermore, there were 419 and 421 RNA editing sites were detected in Aksu Fuji and Ralls Janet, respectively. Analyses of coding usage bias, nucleotide diversity, selection pressure, and genetic distance revealed that the mt genomes of the two cultivars were highly conserved. Phylogenetic analysis of 29 Rosaceae species showed that Aksu Fuji and Ralls Janet clustered with Malus baccata and M. kansuensis. This study provides new insights into the genetics, systematics, and evolution of apple mt genomes.

SpringerLink
LaborjournalApr 11, 2025
Wissenschaftliche #Hypothesen zu formulieren, ist leicht. Die meisten davon – auch sehr plausible – landen indes auf dem Kaffeetisch, weil man sie nicht mit Experimenten testen kann. Zwei Beispiele zur #Drosophila-Ernährung und zum #RNAEditing bei Tintenfischen: https://www.laborjournal.de/editorials/3224.php
Wissenschaftliche Hypothesen taugen nur etwas, wenn sie experimentell testbar sind

und DrosophilaErnhrung ...

Laborjournal
Pierre BarraudNov 21, 2024
📚 Our latest paper "Dimerization of ADAR1 modulates site-specificity of RNA editing" is finally out at Nature Communications 🧑‍🔬👩‍🔬 Structural insights led to an engineered mutant, offering a molecular tool for targeting dimerization. 🎯 Read more about the fascinating interplay between ADAR1 dimerization and RNA editing in our study conducted with M. Jantsch Lab (MedUni Vienna): https://www.nature.com/articles/s41467-024-53777-2 🧬#RNAEditing #ADAR1 #MolecularBiology
Dimerization of ADAR1 modulates site-specificity of RNA editing - Nature Communications

This study reveals that ADAR1 dimerization influences the site-specificity of RNA editing without fully inhibiting its activity, offering new insights into how ADAR1 selects RNA targets and potential ways to modulate its function.

Nature
Pierre BarraudDec 22, 2023
📚 Our latest preprint "Dimerization of ADAR1 modulates site-specificity of RNA editing" unveils the intricate role of ADAR1 homodimerization in editing efficiency. 🧑‍🔬👩‍🔬 Structural insights led to an engineered mutant, offering a molecular tool for targeting dimerization. 🎯 Read more about the fascinating interplay between ADAR1 dimerization and RNA editing in our preprint conducted with M. Jantsch Lab (MedUni Vienna): https://www.biorxiv.org/content/10.1101/2023.12.05.570066v1 🧬#RNAEditing #ADAR1 #MolecularBiology
LaborjournalOct 13, 2023
Manch evolutionärer Wandel geschieht völlig ohne Selektions- und Anpassungsdruck. In unserer Freitags-Kolumne erklären wir das genauer an den Beispielen "Fliegende Toaster" und "#RNAEditing": 👉 https://www.laborjournal.de/editorials/2851.php #Evolution
Nicht alle Evolutionsvorgänge geschehen als Anpassung

Manch evolutionärer Wandel geschieht ohne Anpassungsdruck Zum Beispiel auch durch nichtadaptiven Genetic Drift Eine Erklärung an den Beispielen Fliegende Toaster und RNAEditing

Laborjournal
SPQRJul 4, 2023
"Machine learning and deep learning are showing their strength in genomics because they can take advantage of the huge datasets that can now be generated by modern high-throughput experiments. Importantly, we were also able to use 'interpretable machine learning' to understand why the model predicts that a specific guide will work well" #biotechnology #CRISPR #Genetics #MolecularBiology #RNAediting https://phys.org/news/2023-06-ai-combined-crispr-precisely-gene.html
AI combined with CRISPR precisely controls gene expression

Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology.

Phys.org
Show threadStephen Matheson🌵🌲Jun 12, 2023

The bad:

"Nevertheless, these mechanisms yield viral selection. APOBEC expression in cancers leads to DNA damage and tumor cell death, yet allows for immune escape variants."

The verdict:

"Indeed, APOBECs are fickle friends."

#mutation
#cancer
#Apobec
#viruses
#virology
#RNAediting

Victoria Stuart 🇨🇦 🏳️‍⚧️Jun 12, 2023

Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
https://www.cell.com/cell/fulltext/S0092-8674%2823%2900523-8

• Octopus bimaculoides increase A-to-I RNA editing at >20,000 sites in the cold
• Editing shifts occur within hours, observed in wild populations
• As a functional example, one cold-induced site alters kinesin motility
• Another cold-induced site alters Ca2+-binding affinity of synaptotagmin

Discussion: https://news.ycombinator.com/item?id=36278739

#octopus #cephalopod #RNAediting #CentralDogma #DNA #RNA