Bob šØš¦š²š½šŗš¦Giant Study Reveals Why Some Viruses Hide Inside Your Body For Life
https://www.sciencealert.com/giant-study-reveals-why-some-viruses-hide-inside-your-body-for-life
Levka"Youāre likely already infected with a brain-eating virus youāve never heard of
Fatal brain infection was thought to be from profound immune suppression. Not anymore.
Thereās a virus you may have never heard of before that is estimated to infect up to 90 percent of people and lurks quietly in your cells for lifeābut if it becomes activated, it will destroy your brain. If thatās not startling enough, researchers reported this week that there may be a new way for this virus to activateāone that affects up to 10 percent of adults worldwide.
The virus is the human polyomavirus 2, commonly called either the JC virus or John Cunningham virus, named after the poor patient from whom it was first isolated in 1971. It shows up in the urine and stool of infected people and spreads via the fecal-oral route. Many people are thought to be infected early in life, and blood testing surveys have suggested that 50ā90 percent of adults have been exposed at some point."
"Youāre likely already infected with a brain-eating virus youāve never heard of
Fatal brain infection was thought to be from profound immune suppression. Not anymore.
Thereās a virus you may have never heard of before that is estimated to infect up to 90 percent of people and lurks quietly in your cells for lifeābut if it becomes activated, it will destroy your brain. If thatās not startling enough, researchers reported this week that there may be a new way for this virus to activateāone that affects up to 10 percent of adults worldwide.
The virus is the human polyomavirus 2, commonly called either the JC virus or John Cunningham virus, named after the poor patient from whom it was first isolated in 1971. It shows up in the urine and stool of infected people and spreads via the fecal-oral route. Many people are thought to be infected early in life, and blood testing surveys have suggested that 50ā90 percent of adults have been exposed at some point.
Researchers hypothesize that the initial site of infection is the tonsils, or perhaps the gastrointestinal tract. But wherever it happens, that initial infection is asymptomatic. At that point, a person is infected with whatās called the archetype JC virus, which quietly sets up a persistent but utterly silent lifelong infection.
For the vast majority of people, that is all their JC virus infection will beāsilent. But for an unlucky few, the JC virus will seemingly awaken, rearrange its genetic material, and morph into a brain-demolishing nightmare that causes a disease called progressive multifocal leukoencephalopathy or PML."
HomepageLuxury Cruise Descends Into a Diarrhea Nightmare
https://fed.brid.gy/r/https://futurism.com/health-medicine/cruise-norovirus-diarrhea
Ivi Choc#infectiousdiseases #epidemics #pandemics #outbreak #viruses #adaptation
Havens et al. 6 March 2026, Cell
Dynamics of natural selection preceding human viral epidemics and pandemics
"Viral adaptation is not a necessary precursor to outbreaks of novel zoonotic viruses"
doi.org/10.1016/j.ce...
Redirecting
Redirecting
Ivi Choc#infectiousdiseases #epidemics #pandemics #viralAdaptation #outbreak #virus #viruses #adaptation
Original open access article
Havens et al. 6 March 2026, Cell [InPress, Corrected Proof]
Dynamics of natural selection preceding human viral epidemics and pandemics
"Viral adaptation is not a necessary precursor to outbreaks of novel zoonotic viruses"
LeszekPhage antirestriction induced system (PARIS) protects bacteria from viral infections by cleaving viral tRNAs and T5 phage escaping it by expression of a lysine transfer RNA variant that is not cleaved by PARIS
#armsRace #biology #bacteria #viruses
https://www.biorxiv.org/content/10.1101/2025.07.24.666596v1
https://www.nature.com/articles/s41586-024-07874-3
Bacterial Schlafens mediate anti-phage defense
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of life, its function in prokaryotes has remained unclear. Here, we show that prokaryotic Schlafen nucleases (pSlfns) are widespread antiviral effectors that protect bacteria from phages. These nucleases are fused to diverse protein domains that sense phage infection. We focus on a system where Schlafen nuclease is fused to a previously unknown immunoglobulin-like sensor domain and demonstrate that it recognizes T5-like phage tail assembly chaperones and cleaves both bacterial and viral tRNA, triggering abortive infection. Our findings redefine Schlafens as an ancient, mechanistically conserved family of immune effectors, revealing the deep evolutionary origin of tRNA-targeting antiviral immunity in humans. ### Competing Interest Statement A. Nemudryi and A. Nemudraia are inventors on patents and patent applications related to CRISPR-Cas and Schlafen immune systems and applications thereof. National Institutes of Health, R00AI171893
Howard Smith MD, AMNasal Spray Turbocharges Immunity. A multipurpose vaccine in a nasal spray could someday protect against life-threatening viruses including flu, pneumonia, even CoVid as well as multiple allergies. #viruses #allergen #immunity #nasalspray
https://www.instagram.com/p/DVtz5K6AKlf/
https://www.instagram.com/p/DVtz5K6AKlf/
Howard G. Smith MD, AM on Instagram: "Nasal Spray Turbocharges Immunity A multipurpose vaccine in a nasal spray could someday protect against life-threatening viruses including flu, pneumonia, even CoVid as well as multiple allergies. It works by boosting your lungsā immune defenses rather than targeting a specific virus or allergen. Thatās a fascinating development from microbiologists and immunologists at Stanford Medicine, published in the journal Science. Instead of chasing constantly mutating viruses, this approach ātrainsā the immune system to stay on high alert for months. The study was conducted in mice, not humans. In experimental groups receiving the nasal vaccineāup to three doses spaced one week apartāanimals are protected from viruses for at least three months, with viral levels reduced by about 700-fold. All vaccinated mice survive infection, with minimal weight loss and minimal lung inflammation. In contrast, unvaccinated control mice develop severe illness, significant weight loss, high viral loads, and often die. Besides working against viruses, the vaccine also protects against bacterial infections like Staphylococcus aureus and, wait for it, reduces allergic airway inflammation. So its an allergy medicine too. For the average person, this research suggests a future where one nasal spray could potentially replace multiple seasonal vaccines and provide rapid protection against new respiratory threats. However, this is still early-stage animal research, and human trials are just beginning. If successful, the approach could simplify vaccination and improve pandemic preparednessābut itās not available yet. https://med.stanford.edu/news/all-news/2026/02/universal-vaccine.html https://www.sciencedaily.com/releases/2026/02/260222092258.htm #viruses #allergen #immunity #nasalspray"
0 likes, 0 comments - drhowardsmithreports on March 10, 2026: "Nasal Spray Turbocharges Immunity A multipurpose vaccine in a nasal spray could someday protect against life-threatening viruses including flu, pneumonia, even CoVid as well as multiple allergies. It works by boosting your lungsā immune defenses rather than targeting a specific virus or allergen. Thatās a fascinating development from microbiologists and immunologists at Stanford Medicine, published in the journal Science. Instead of chasing constantly mutating viruses, this approach ātrainsā the immune system to stay on high alert for months. The study was conducted in mice, not humans. In experimental groups receiving the nasal vaccineāup to three doses spaced one week apartāanimals are protected from viruses for at least three months, with viral levels reduced by about 700-fold. All vaccinated mice survive infection, with minimal weight loss and minimal lung inflammation. In contrast, unvaccinated control mice develop severe illness, significant weight loss, high viral loads, and often die. Besides working against viruses, the vaccine also protects against bacterial infections like Staphylococcus aureus and, wait for it, reduces allergic airway inflammation. So its an allergy medicine too. For the average person, this research suggests a future where one nasal spray could potentially replace multiple seasonal vaccines and provide rapid protection against new respiratory threats. However, this is still early-stage animal research, and human trials are just beginning. If successful, the approach could simplify vaccination and improve pandemic preparednessābut itās not available yet. https://med.stanford.edu/news/all-news/2026/02/universal-vaccine.html https://www.sciencedaily.com/releases/2026/02/260222092258.htm #viruses #allergen #immunity #nasalspray".
Stefan F. Wirth@PLOSBiology very interesting study about the impact of #marine #viruses on the #microbiological dynamics. The researches collected #oceanwater, purified #viralparticles from it and created #sequences of the #metagenomes of these viruses, which they used for the characterization of virus community #dynamics.
SPAAM-communityIt's #MetagenomicsMonday again! š§¬š§¬š§¬Today, we are leaving you with the new study on #HHV-6. Ancient #genomes revealed that modern HHV-6 diversity was already established centuries ago and that germline integrations stem from ancient founder events.
https://www.science.org/doi/10.1126/sciadv.adx5460
#SPAAM #aDNA #sixthdisease #roseola #pathogengenomics #ancientpathogens #viruses #evolution
https://www.science.org/doi/10.1126/sciadv.adx5460
#SPAAM #aDNA #sixthdisease #roseola #pathogengenomics #ancientpathogens #viruses #evolution