Stephen Matheson🌵🌲
Thiago Carvalho"We identified and validated APOBEC3A and APOBEC4 as novel #ribosome biogenesis factors through our laboratory's established screening platform for the discovery of regulators of nucleolar function in MCF10A cells."
The bad:
"Nevertheless, these mechanisms yield viral selection. APOBEC expression in cancers leads to DNA damage and tumor cell death, yet allows for immune escape variants."
The verdict:
"Indeed, APOBECs are fickle friends."