Amelia Cervera π§¬Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms.
#Transposons #TEs #CancerEvolution #AluRepeats #LINE1 #ADAR1
https://www.cell.com/immunity/fulltext/S1074-7613(24)00494-1
Pierre Barraudπ Our latest paper "Dimerization of ADAR1 modulates site-specificity of RNA editing" is finally out at Nature Communications π§βπ¬π©βπ¬ Structural insights led to an engineered mutant, offering a molecular tool for targeting dimerization. π― Read more about the fascinating interplay between ADAR1 dimerization and RNA editing in our study conducted with M. Jantsch Lab (MedUni Vienna): https://www.nature.com/articles/s41467-024-53777-2 π§¬#RNAEditing #ADAR1 #MolecularBiology
Dimerization of ADAR1 modulates site-specificity of RNA editing - Nature Communications
This study reveals that ADAR1 dimerization influences the site-specificity of RNA editing without fully inhibiting its activity, offering new insights into how ADAR1 selects RNA targets and potential ways to modulate its function.
π Our latest preprint "Dimerization of ADAR1 modulates site-specificity of RNA editing" unveils the intricate role of ADAR1 homodimerization in editing efficiency. π§βπ¬π©βπ¬ Structural insights led to an engineered mutant, offering a molecular tool for targeting dimerization. π― Read more about the fascinating interplay between ADAR1 dimerization and RNA editing in our preprint conducted with M. Jantsch Lab (MedUni Vienna): https://www.biorxiv.org/content/10.1101/2023.12.05.570066v1 π§¬#RNAEditing #ADAR1 #MolecularBiology