"These powerful tools reveal the ‘control knobs’ of the genome
By accelerating the identification of DNA sequences that control gene expression, assays are revealing the hidden grammar of the regulatory genome — and giving scientists the means to rewrite it.
For all that scientists talk of ‘decoding the genome’, the messy reality is that the genome isn’t even written in a single language. Scientists are fluent in the three-nucleotide codons that make up the protein-coding genes in DNA, but these represent only about 2% of the genomic text. The remainder is written in an entirely distinct language, which researchers are yet to untangle."








