Mastodawn

Researchers identified the repurposed drug #Sildenafil as a highly promising and effective treatment capable of improving the disease course of Leigh Syndrome, a severe and previously untreatable #mitochondrial disorder affecting brain energy metabolism.
#Neurology #CellBiology #MolecularBiology #Pharmaceutical #sflorg
https://www.sflorg.com/2026/03/cbio03112601.html

New therapy approach for Leigh Syndrome

Leigh Syndrome is an inherited, progressive disease that affects the brain.

Scientific Frontline Mar 9

Researchers at Rice University and Baylor College of Medicine utilized a non-editing #CRISPR technique to safely increase #mitochondrial production in heart cells, improving cellular energy levels without causing cellular burnout or malfunction.
#MolecularBiology #Bioengineering #Genetics #sflorg
https://www.sflorg.com/2026/03/mbio03092601.html

CRISPR-based technique unlocks healing power of mitochondria for heart failure therapy

After a heart attack, the heart struggles to recoup and maintain energy. One third of patients develop heart failure as a result

Scientific Frontline Mar 9

Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html

Paternal mitochondria turn out to be less rare than thought

Why those organelles are inherited only through the mother is still unclear.

JIPB Sep 24

#Mitochondrial complex I (CI) assembly in plants is a complex, crucial process.
Chen et al. provide insights into CI assembly pathways in #maize 🌽and discuss the critical role of ZmGLDH and CRK1 in CI assembly.

https://doi.org/10.1111/jipb.13958

@wileyplantsci
#PlantScience #JIPB #RNA #botany

PLOS Biology Jul 22, 2025

#Mitochondrial proteins are synthesized with presequences that target them to the #mitochondrion, but why are some more efficient than others? This study identifies presequences which recruit Hsp90 co-chaperones & TOMM34 to confer prioritized import efficiency @PLOSBiology plos.io/4m6spBN

PLOS Biology Jun 25, 2025

What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2

PLOS Biology May 23, 2025

#Fungal infections are hard to treat due to #DrugResistance. @blake_billmyre &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @PLOSBiology https://plos.io/4dz3iVm

ISOGG Feb 14, 2025

“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj

https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.16816

ISOGG Jan 25, 2025

“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock

https://pmc.ncbi.nlm.nih.gov/articles/PMC11751369/

Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood

The pace of biological aging varies between people independently of chronological age and mitochondria dysfunction is a key hallmark of biological aging. We hypothesized that higher functional impact (FI) score of mitochondrial DNA (mtDNA) variants ...

PubMed Central (PMC)