Giuseppe MichieliEnhanced #genome #replication activity of pandemic #H1N1 #influenza A virus through PA #mutations, https://etidiohnew.blogspot.com/2025/12/enhanced-genome-replication-activity-of.html
Emergence of #mammalian-adaptive #PB2 #mutations enhances #polymerase activity and #pathogenicity of #cattle-derived #H5N1 #influenza A virus, https://etidiohnew.blogspot.com/2025/12/emergence-of-mammalian-adaptive-pb2.html
Host switching #mutations in #H5N1 #influenza hemagglutinin suppress site-specific activation dynamics, https://etidiohnew.blogspot.com/2025/12/host-switching-mutations-in-h5n1.html
CSBJ🧬 How do changes in a non-catalytic residue collapse an entire enzyme’s function?
🔗 Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.014
📚 CSBJ: https://www.csbj.org/
#Biophysics #Enzymology #StructuralBiology #Mutations #ProteinFolding
Scientific FrontlineFor a long time, #evolutionary #biologists have thought that the #genetic #mutations that drive the #evolution of #genes and proteins are largely neutral: they’re neither good nor bad, but just ordinary enough to slip through the notice of selection.
#EvolutionaryBiology #sflorg
https://www.sflorg.com/2025/11/ebio11162501.html
#EvolutionaryBiology #sflorg
https://www.sflorg.com/2025/11/ebio11162501.html
''The pronounced spread of #BA322 in #Perth (population ~2 million) and its detection in #Sydney on Sept 3, 2025, (EPI_ISL_20187886, GISAID) might allow this #variant to gain adaptive #mutations. Some Australian viruses now carry unique S protein changes—T259I and P1162L. ''
SNES-FSU#Mutations Règles du mouvement, barème et pièces à fournir, informations sur les mouvements sur postes spécifiques et POP, analyses et demandes du SNES-FSU... Retrouvez dans ce supplément les informations indispensables pour préparer votre participation au mouvement !
https://www.snes.edu/publications/les-supplements-de-lus/mutations-2026-supplement-de-lus-n864/
https://www.snes.edu/publications/les-supplements-de-lus/mutations-2026-supplement-de-lus-n864/
DuncanHonourable mentions:
The Bug Club (wonky indie pop)
Ditz (queer, loud)
Mên An Tol (a bit like if Oasis held up to listening to now)
Skydaddy (pop/soft rock with additional instruments)
Waldo's Gift (instrumental electro-backed guitar wonkery)
Scaler (formerly Scraping) (dance-rock with intense visuals - did a better gig a few years ago, but still class)
Almost everything was good and enjoyable though. And things that weren't were got at least one.
Mutations festival highlights for me:
Party Dozen (loud, wonky drums n sax)
Adult DVD (driving electro-punk)
Ceann Capaill (soundscapes and poetry)
Coilguns (Swiss hardcore/noise, lovely lads)
Lynks (explicit, queer pop - drag-influenced but not drag)
Opus Kink (party rock with horns)
A fraction of stuff I couldn't fit in: Lambrini Girls, Teke::Teke, MadMadMad, Y, YANNG, Big Special, Vraell. Plus Pigsx7, seen them before - they're great.
Another edition of Mutations Festival finished in (not so this time of the year) sunny #BrightonAndHove - yes, at 2am. A rare chance for an early morning gig - a very special vibe if you make it there still wanting live music!
A few duds but generally really good quality this year - both days have been rough outside of the music but the gigs generally buoyed me, rather than events dragging the music down. Which isn't a given.
Highlights follow tomorrow!