"In another post, #Trump claimed that #DrugPrices were dropping “500 percent, 600 percent, 700 percent and more,” a mathematical impossibility that would require #pharmaceutical companies to pay customers to take medications."

https://www.meidasplus.com/p/saturday-afternoon-news-updates-112925

#DementiaDon

Saturday Afternoon News Updates - 11/29/25

I'm following all the news this weekend so you don't have to

Meidas+
Researchers have decoded the signaling pathway that inhibits #nerve #regeneration in #diabetes and have developed a therapeutic peptide that could transform the treatment—and possibly even the prevention—of diabetic nerve damage.
#Biomedical #Pharmaceutical #sflorg
https://www.sflorg.com/2025/11/bmed11272501.html
Possible therapeutic approach to treat diabetic nerve damage discovered

For the first time, our results show that diabetic nerve healing can be brought back

Occurrence, distribution, and risk assessment of selected pharmaceuticals in municipal biosolids from the four wastewater treatment plants in Gauteng Province, South Africa. #pharmaceutical #wastewater #Africa #biosolids https://www.nature.com/articles/s41598-025-29215-8
Occurrence, distribution, and risk assessment of selected pharmaceuticals in municipal biosolids from the four wastewater treatment plants in Gauteng Province, South Africa - Scientific Reports

The presence of pharmaceutical residues in municipal biosolids is an emerging environmental concern due to their potential accumulation in agricultural soils following land application. While parent compounds like sulfamethoxazole and carbamazepine are frequently studied, data on their transformation products in biosolids remain limited. This study assessed the occurrence, distribution, and environmental risks of sulfamethoxazole, carbamazepine, and two of their selected metabolites in biosolids collected from four wastewater treatment plants (WWTPs) in Gauteng Province, South Africa. A single biosolid sampling campaign was conducted across the four WWTPs, each characterized by varying operational parameters. Sulfamethoxazole and its two metabolites were not detected in any of the samples. In contrast, carbamazepine and its metabolites—carbamazepine-10,11-epoxide and carbamazepine diol—were detected, with maximum concentrations of 150.67, 601.95, and 89.18 ng/g dry weight, respectively. Carbamazepine and carbamazepine-10,11-epoxide occurred in all samples, while carbamazepine diol appeared in 50% of the samples. The concentration patterns varied across WWTPs and were significantly correlated with biosolid pH, organic carbon content, and oxidation-reduction potential. Risk quotient analysis indicated that the predicted soil concentrations of carbamazepine (0.50 ng/g dry weight) pose negligible ecological risk (RQ = 0.003). However, due to a lack of ecotoxicological data, environmental risks associated with carbamazepine-10,11-epoxide and carbamazepine diol could not be fully assessed. Overall, the findings highlight the persistence of carbamazepine and its metabolites in biosolids and underscore the importance of optimizing sludge treatment processes and generating toxicity data for pharmaceutical metabolites to support safe land application practices.

Nature
Occurrence, distribution, and risk assessment of selected pharmaceuticals in municipal biosolids from the four wastewater treatment plants in Gauteng Province, South Africa. #pharmaceutical #wastewater #Africa #biosolids https://www.nature.com/articles/s41598-025-29215-8
Occurrence, distribution, and risk assessment of selected pharmaceuticals in municipal biosolids from the four wastewater treatment plants in Gauteng Province, South Africa - Scientific Reports

The presence of pharmaceutical residues in municipal biosolids is an emerging environmental concern due to their potential accumulation in agricultural soils following land application. While parent compounds like sulfamethoxazole and carbamazepine are frequently studied, data on their transformation products in biosolids remain limited. This study assessed the occurrence, distribution, and environmental risks of sulfamethoxazole, carbamazepine, and two of their selected metabolites in biosolids collected from four wastewater treatment plants (WWTPs) in Gauteng Province, South Africa. A single biosolid sampling campaign was conducted across the four WWTPs, each characterized by varying operational parameters. Sulfamethoxazole and its two metabolites were not detected in any of the samples. In contrast, carbamazepine and its metabolites—carbamazepine-10,11-epoxide and carbamazepine diol—were detected, with maximum concentrations of 150.67, 601.95, and 89.18 ng/g dry weight, respectively. Carbamazepine and carbamazepine-10,11-epoxide occurred in all samples, while carbamazepine diol appeared in 50% of the samples. The concentration patterns varied across WWTPs and were significantly correlated with biosolid pH, organic carbon content, and oxidation-reduction potential. Risk quotient analysis indicated that the predicted soil concentrations of carbamazepine (0.50 ng/g dry weight) pose negligible ecological risk (RQ = 0.003). However, due to a lack of ecotoxicological data, environmental risks associated with carbamazepine-10,11-epoxide and carbamazepine diol could not be fully assessed. Overall, the findings highlight the persistence of carbamazepine and its metabolites in biosolids and underscore the importance of optimizing sludge treatment processes and generating toxicity data for pharmaceutical metabolites to support safe land application practices.

Nature

Last week, we presented our new NWE #Interreg project #PREWAPHARM at the Campus Earth day at the University of #Münster. Turns out that many people are already aware of the problems that #pharmaceutical residues can cause in our #water bodies and we had some great discussion on ways to solve this problem. In PREWAPHARM, we are working on microbial solutions to remove harmful compounds directly at the source, e.g. hospitals, care facilites, remote communities.

@uni-muenster.de

Somewhere in a secret corporate lab is a group of insane subjects who are attended to by nurses with microphones who record their ravings. These recordings are forwarded to advertising agencies who mine them for uttterances like "BIMZELX!" which eventually become product names.

#pharmaceutical #advertising #wtf

https://www.wacoca.com/news/2698791/ 【欧州市況】株は全面安、高リスク資産を敬遠-英国債軟調 – Bloomberg #cojp #CommoditiesMarkets #Europe #Pharmaceutical #science #ヨーロッパ #欧州
https://www.walknews.com/1121366/ 【欧州市況】株は全面安、高リスク資産を敬遠-英国債軟調 – Bloomberg #cojp #CommoditiesMarkets #Europe #EuropeNews #pharmaceutical #Science #ヨーロッパ #ヨーロッパニュース #欧州
https://www.walknews.com/1120914/ 米厚生長官、ワクチン中のアルミニウム塩と食物アレルギーの関連示唆 – Bloomberg #cojp #CommoditiesMarkets #News #pharmaceutical #Science #World #WorldNews #ニュース #世界 #世界ニュース