Mastodawn

🧠 Exciting News! Our review article is published!
We explore how miRNAs could enhance diagnostics and their role in PTM and Aging 🧠🧬
🔗https://doi.org/10.3389/fnmol.2024.1386735
🔗 https://go.nature.com/3FSQrke

#MicroRNA #Neurodegeneration #PostTranslationalModifications #AgingAndDisease #MolecularNeuroscience #RNARegulation #GeneExpression #Biomarkers #EarlyDiagnosis #FrontiersInNeuroscience #ScientificResearch #BTU #Charite #DZNE #BrainHealth #Epigenetics #NextGenDiagnostics #Neurobiology #miRNABasedDiagnostics

Frontiers | MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review

Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leadi...

Frontiers

Husnain Apr 20

🧠 Review alert! Our article explores microRNAs (miRNAs) as early, non-invasive biomarkers for neurodegenerative diseases like Alzheimer’s & Parkinson’s. A step toward next-gen diagnostics & precision medicine!
🔗https://doi.org/10.3389/fnmol.2024.1386735
#MicroRNA #Neurodegeneration #PostTranslationalModifications #AgingAndDisease #MolecularNeuroscience #RNARegulation #GeneExpression #Biomarkers #Alzheimers #Parkinsons #Multiplesclerosis #Huntingtons #EarlyDiagnosis #ScientificResearch #FrontiersInNeuroscience

Frontiers | MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review

Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leadi...

Frontiers

John Vaccaro (johniac)Feb 28

SciTech Chronicles. . . . . . . . .Feb 28, 2025

https://bit.ly/stc022825

#corn #earworm #flavonoids #microbiome ##Quantum-computing #linking #connectivity #12-qubit ##Vesuvius #brain #X-rays #vitrification #microbes #modules #free-living #ecosystem #bamboo #microRNA #feeding #regulators

SciTech Chronicles. . . . . . . . .Feb 28th, 2025

Some make amends... Some make a wound. Vol II No 53 315 links Curated flavonoidcompounds have an insecticidal effect on corn earworm larvae....

Cytology and Genetics Jan 28

A Comprehensive Review on Liver Regeneration Termination: A Non-Neglectable Phase - #liverregenerationtermination #cellinvolvement #cytokines #signalingpathways #gutmicrobiota #microRNA #liverregeneration #liver - https://link.springer.com/article/10.3103/S0095452724040030

A Comprehensive Review on Liver Regeneration Termination: A Non-Neglectable Phase - Cytology and Genetics

Abstract As the most important organ of detoxification in the body, the liver also has the strong regenerative ability itself. The liver can regenerate after partial hepatectomy (PH) and completely restore to its original mass. Liver regeneration (LR) has become one of research hotspots in the field of regenerative biology. Previous basic studies have predominantly concentrated on the initial and proliferative phases of regenerative response, while a relatively little attention has been paid to the mechanism of proper termination of liver regeneration. In recent years, along with the increasing recognition of the significance of LR termination, the growing researches have been carried out and some achievement has been made in a certain extent. The successful completion of LR is considered to involve many cells, growth factors, signaling pathways, metabolites and other extrahepatic factors. This article will review the progression of research on the mechanism of LR termination after PH in recent years.

SpringerLink

Cytology and Genetics Jan 22

Role of MicroRNA Modulated Wnt Pathway in Breast Cancer and Its Therapeutic Use - #Wntpathway #breastcancer #MicroRNA #nanocarrier #therapeutics #cancer #Wnt - https://link.springer.com/article/10.3103/S0095452724040108

Role of MicroRNA Modulated Wnt Pathway in Breast Cancer and Its Therapeutic Use - Cytology and Genetics

Abstract The Wnt pathway plays a key role in cell growth, survival, and self-renewal which is frequently hyperactive in various cancers. It is categorized into canonical and non-canonical Wnt pathways depending upon the influence of the β-catenin protein. Gene expressions are often altered by small non-coding RNAs, known as microRNAs (miRNAs) leading to regulation involving cell-proliferating pathways like Wnt in various cancers, including breast. miRNAs frequently act as an oncogene or a tumor-suppressor depending upon their regulatory roles. In this review article, the significance of the Wnt pathway in cancer progression, most importantly breast cancer is widely explained. The role of miRNAs in modulating varied pathways especially the Wnt pathway in breast cancer is also reviewed here. Breast cancer suppression using new-age miRNA therapeutics is showing promising results and the use of different nanocarriers for therapeutic delivery is increasing its efficacy. Targeting the Wnt pathway and its related genes can show a new path for the treatment of cancer stem cells (CSCs) of breast and other cancers as the Wnt pathway plays a pivotal role in maintaining the stemness of CSCs. Moreover, controlling the Wnt pathway through miRNA nanocarrier can give another dimension to breast cancer therapy by inhibiting aggressive and tricky breast cancer stem cells.

SpringerLink

Show thread

RoedigerRG Jan 20

@mick @UlrikeHahn

Unfortunately, at the moment we (#NeuroMiR project) cannot show something, but hopefully in the future we can show our multiplex microbead based-technology how to quantify certain biomarkers based on proteins and #microRNA for detection and quantification of neurodegenerative processes.

P.S.: Hope my statement ages well.
#Neuroscience